Investigating a new target for treating major depressive disorder using brain imaging

Who could benefit from this research

What this research studies

This research explores the role of the vesicular acetylcholine transporter (VAChT) in major depressive disorder (MDD) by using advanced brain imaging techniques. Researchers will visualize and quantify VAChT levels in the brain using a specialized PET tracer, aiming to understand how these levels relate to depression severity. The study builds on previous findings that suggest a link between low VAChT levels and increased acetylcholine, which may contribute to MDD. By validating this hypothesis, the research seeks to lay the groundwork for future therapeutic developments targeting the cholinergic system in depression.

Why it matters

Where this research is happening

• State University New York Stony Brook
  Stony Brook, United States Active

Researchers

• Principal investigator: Parsey, Ramin V. — State University New York Stony Brook
• Study coordinator: Parsey, Ramin V.

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.