Efficient photostress recovery biomarkers for age-related macular degeneration
Official title: Efficient Achromatic and Chromatic Photostress Recovery Assessment for Age-related Macular Degeneration
Funded at Perzeption INC. · NIH-11310564 · Data updated 2026-11-12
A small NIH-funded project will test quick, easy biomarkers of how well people with age-related macular degeneration recover after light exposure to help track disease progression and treatment effects.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Perzeption INC. NIH-funded |
| Lab location | 1 site (Littleton, UNITED STATES) |
| Project start | September 1, 2026 |
| Project end | August 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $305,406 |
| NIH project number | 1R43EY038518-01 |
| Project ID | NIH-11310564 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults 21 years and older with AMD or related age-related macular conditions.
✕Less likely to help
Individuals without AMD or without a functional retina may not benefit from these tests.
What this research studies
This project aims to develop and test simple tests that measure how fast people with AMD recover sensitive vision after bright light. It focuses on both achromatic and chromatic photostress recovery to capture different aspects of retinal function. By using streamlined methods that don’t require highly specialized labs, it seeks to provide practical biomarkers that could be used in clinics and future trials. Participants will include adults aged 21 and older with AMD or related eye conditions.
Why it matters
Potential benefit: If successful, patients could benefit from quicker, more accessible ways to monitor AMD progression and response to treatments.
How similar studies have gone: Prior work shows photostress recovery changes in AMD, but streamlined, clinic-friendly tests are still being developed.
Where this research is happening
-
Perzeption INC.
Littleton, United States Active
Researchers
- Principal investigator: Wilmerding, Thaddeus Orion — Perzeption INC.
- Study coordinator: Wilmerding, Thaddeus Orion
Related research
Other NIH-funded projects on the same topics.
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-
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-
Transplanting stem-cell–derived retinal cells to treat dry AMD
A medical team is testing a stem cell therapy to replace damaged retinal cells in adults with dry age-related macular degeneration.
-
RPESC-derived RPE Transplant for Dry AMD in adults
A new cell-based therapy derived from RPESCs is being tested to help adults with dry age-related macular degeneration regain vision.
-
New high-resolution OCT biomarkers to map early AMD changes
A new imaging approach using advanced OCT methods will help doctors see early changes in age-related macular degeneration to guide treatment and improve quality of life for older adults.
-
Targeting inflammation in age-related macular degeneration
Aims to understand how inflammation drives age-related macular degeneration in people and explore new targets to slow or stop vision loss.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.