Using structured light to detect early signs of age-related macular degeneration
Official title: Direct Discrimination of Quantum States by the Human Eye With Macular Degeneration
Run by Centre for Eye and Vision Research · NCT05913063 · Data updated 2026-11-12
This study is testing a new way to spot early signs of age-related macular degeneration using special light techniques to see if it can help people with vision problems get diagnosed sooner.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 50 (estimated) |
| Sponsor | Centre for Eye and Vision Research Academic / other |
| Locations | 1 site (Hong Kong, Guangdong) |
| Status | Recruiting |
| Started | June 26, 2023 |
| Main results expected | July 1, 2029 |
| Study ends | October 1, 2029 |
| Registry record updated | March 18, 2026 |
| Trial ID | NCT05913063 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include older adults diagnosed with age-related macular degeneration or glaucoma, as well as age-matched individuals with normal vision.
✕Probably not a fit
Patients with additional eye diagnoses or conditions may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to improve the early diagnosis of age-related macular degeneration (AMD) by utilizing structured light imaging microscopy techniques derived from quantum information science. By projecting polarization-coupled orbital angular momentum states of light onto the retina, the researchers hope to create specific visual patterns that can reveal changes in the macula before significant vision loss occurs. The study will involve participants with various vision conditions, including those with AMD and glaucoma, as well as age-matched controls with normal vision. This innovative approach seeks to enhance the precision of AMD detection and potentially lead to better patient outcomes.
Why it matters
Potential benefit: If successful, this method could enable earlier detection of AMD, allowing for timely interventions that may prevent vision loss.
How similar studies have gone: While the application of structured light in vision sciences is novel, similar approaches in other fields have shown promise, indicating potential for success.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Participants who are clinically diagnosed with a vision disease affecting their macula * Older adults who are matched for age. * Participants who are clinically diagnosed with glaucoma * Participants who have normal vision. * One aged-matched control with normal vision will be recruited for each of the diagnosed groups (born in the same year). Exclusion Criteria: * Participants with any additional eye diagnosis or condition
Where it's running
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Centre for Eye and Vision Research Limited
Hong Kong, Guangdong, Hong Kong Recruiting
Study contacts
- Principal investigator: Benjamin Thompson, PhD — Centre for Eye and Vision Research
- Study coordinator: Benjamin Thompson, PhD
- Email: ben.thompson@cevr.hk
- Phone: +852-3169-9631
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.