Understanding Age-Related Macular Degeneration and Its Progression
Official title: Project AMD: Comprehensive Characterisation of Age-Related Macular Degeneration and Its Progression
Run by Center for Eye Research Australia · NCT04739319 · Data updated 2026-11-12
This study looks at how age-related macular degeneration develops and progresses by comparing people with the condition to healthy individuals, using non-invasive tests and personal feedback.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 2500 (estimated) |
| Sponsor | Center for Eye Research Australia Academic / other |
| Locations | 1 site (East Melbourne, Victoria) |
| Status | Recruiting |
| Started | February 2, 2021 |
| Main results expected | November 2040 |
| Study ends | November 2040 |
| Registry record updated | February 9, 2024 |
| Trial ID | NCT04739319 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are individuals aged 18 and older with either diagnosed AMD or normal aging changes in the eyes.
✕Probably not a fit
Patients with ocular or systemic conditions that could interfere with retinal assessment or those unable to provide informed consent may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational project aims to comprehensively characterize age-related macular degeneration (AMD) by investigating its underlying causes, the differences in AMD phenotypes, and the factors influencing disease progression. Participants will include individuals with AMD as well as healthy controls, and data will be collected through non-invasive imaging, biological samples, and patient-reported outcomes. The study seeks to enhance our understanding of AMD's natural history and the rate at which it progresses.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of age-related macular degeneration, potentially reducing vision loss in affected individuals.
How similar studies have gone: Other studies have successfully characterized AMD and its progression, indicating that this approach is supported by existing research.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. 18 years of age or older; and 2. either AMD (defined as having at least a medium druse \>63 um), or having eyes with normal ageing changes (including small drusen ≤63 um) or no abnormalities as control participants Exclusion Criteria: 1. ocular or systemic conditions other than AMD that could compromise retinal assessment or assessment of AMD and its progression; or 2. any participant with any mental or physical impairment that prevents them from signing an informed consent form or participating in this study.
Where it's running
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Centre for Eye Research Australia
East Melbourne, Victoria, Australia Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.