Understanding a Key Component in Age-Related Macular Degeneration
Role of Bruch Membrane Heparan Sulfate in Drusenogenesis in Age-Related Macular Degeneration
['FUNDING_CAREER'] · UNIVERSITY OF CALIFORNIA, SAN DIEGO · NIH-11101418
This work explores how a specific sugar molecule in the eye's support layer contributes to the deposits that cause vision loss in dry age-related macular degeneration.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN DIEGO (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-11101418 on ClinicalTrials.gov |
What this research studies
Age-related macular degeneration (AMD) is a leading cause of blindness, especially the 'dry' form, which currently has no treatments. In dry AMD, fatty deposits called drusen build up in the macula, harming vision. We are looking closely at a part of the eye called Bruch's membrane, specifically focusing on a sugar molecule called heparan sulfate. By understanding how changes in this molecule contribute to drusen formation, we hope to uncover new ways to prevent or treat this condition.
Who could benefit from this research
Good fit: This foundational research is for patients with age-related macular degeneration who are seeking future treatment options.
Not a fit: Patients without age-related macular degeneration would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for early and intermediate dry age-related macular degeneration, a condition for which there are currently no options.
How similar studies have performed: While the general role of these molecules in other diseases is known, their specific contribution to drusen formation in AMD is a relatively new area of focus.
Where this research is happening
LA JOLLA, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN DIEGO — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TOOMEY, CHRISTOPHER B — UNIVERSITY OF CALIFORNIA, SAN DIEGO
- Study coordinator: TOOMEY, CHRISTOPHER B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.