OCT Angiography for Age-related Macular Degeneration
Funded at Oregon Health & Science University · NIH-11379944 · Data updated 2026-11-12
A patient-friendly look at using advanced eye imaging to help diagnose and monitor age-related macular degeneration, with the goal of protecting vision.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project start | September 1, 2014 |
| Project end | May 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $677,638 |
| NIH project number | 5R01EY024544-12 |
| Project ID | NIH-11379944 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults diagnosed with age-related macular degeneration who are undergoing imaging and monitoring.
✕Less likely to help
Patients not undergoing OCTA imaging or not eligible for imaging-based biomarkers may experience no direct benefit.
What this research studies
This project uses a fast OCTA imaging method to see blood flow in the eye’s tiny vessels and to track how AMD progresses or responds to treatment. By improving image quality and developing better biomarkers, clinicians may detect risk of vision loss earlier and tailor care to each person. The study builds on previous findings that OCTA can reveal CNV and other vascular changes, aiming to translate these insights into clearer clinical guidance.
Why it matters
Potential benefit: If successful, this research could lead to earlier detection of AMD progression and more personalized treatment plans to preserve vision.
How similar studies have gone: Prior studies show OCTA can detect CNV and monitor treatment response, supporting further development of imaging biomarkers.
Where this research is happening
-
Oregon Health & Science University
Portland, United States Active
Researchers
- Principal investigator: Jia, Yali — Oregon Health & Science University
- Study coordinator: Jia, Yali
Related research
Other NIH-funded projects on the same topics.
-
AI-powered tool to predict 2-year risk of late AMD
A new AI software helps people at risk of age-related macular degeneration understand their 2-year risk and what steps could protect their vision.
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Active cycling program to support vision and daily living in Veterans with AMD
A 6-month online group spin cycling program is tested to help Veterans with age-related macular degeneration maintain vision and improve daily functioning.
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Transplanting stem-cell–derived retinal cells to treat dry AMD
A medical team is testing a stem cell therapy to replace damaged retinal cells in adults with dry age-related macular degeneration.
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RPESC-derived RPE Transplant for Dry AMD in adults
A new cell-based therapy derived from RPESCs is being tested to help adults with dry age-related macular degeneration regain vision.
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New high-resolution OCT biomarkers to map early AMD changes
A new imaging approach using advanced OCT methods will help doctors see early changes in age-related macular degeneration to guide treatment and improve quality of life for older adults.
-
Targeting inflammation in age-related macular degeneration
Aims to understand how inflammation drives age-related macular degeneration in people and explore new targets to slow or stop vision loss.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.