Investigating a specific genetic change in childhood leukemia
Official title: Experimental and preclinical modeling of NUP98-rearranged acute leukemia
Funded at St. Jude Children's Research Hospital · NIH-10230523 · Data updated 2026-11-12
This study is looking at how changes in a specific gene might contribute to aggressive types of leukemia in kids and teens, with the goal of finding new treatments that could help young patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Jude Children's Research Hospital NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project start | September 19, 2019 |
| Project end | August 31, 2025 |
| Funding year | 2020 |
| Award (this year) | $179,500 |
| NIH project number | 3U54CA243124-01S2 |
| Project ID | NIH-10230523 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children and adolescents diagnosed with NUP98-rearranged acute leukemias.
✕Less likely to help
Patients with other types of leukemia or those without NUP98 rearrangements may not benefit from this research.
What this research studies
This research focuses on understanding the role of a genetic rearrangement involving the NUP98 gene in various aggressive forms of leukemia that affect children and adolescents. By developing and studying both human and mouse models, the researchers aim to uncover the molecular mechanisms behind these leukemias and identify potential treatment vulnerabilities. The project involves a collaborative effort among experts in genomics, leukemia modeling, and drug development to create and test new therapeutic strategies. Patients may have the opportunity to benefit from innovative treatments that arise from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective therapies for high-risk leukemias in children, improving survival rates and outcomes.
How similar studies have gone: Previous research has shown promise in targeting genetic alterations in leukemia, suggesting that this approach could yield significant advancements.
Where this research is happening
-
St. Jude Children's Research Hospital
Memphis, United States Active
Researchers
- Principal investigator: Mullighan, Charles G. — St. Jude Children's Research Hospital
- Study coordinator: Mullighan, Charles G.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.