Investigating a specific genetic alteration in childhood leukemia
Experimental and preclinical modeling of NUP98-rearranged acute leukemia
This study is looking at how certain proteins linked to leukemia in kids and teens work, so researchers can find new ways to treat this tough disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Jude Children's Research Hospital NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project ID | NIH-10228882 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of NUP98 fusion oncoproteins in high-risk myeloid leukemias affecting children and adolescents. By developing and studying human and mouse models, the team aims to uncover the molecular mechanisms behind these leukemias and identify potential vulnerabilities that could be targeted with new therapies. The project involves a collaborative effort among experts in various fields, including genomics and drug development, to create innovative treatment strategies for these aggressive cancers.
Who could benefit from this research
Good fit: Ideal candidates for this research are children and adolescents diagnosed with NUP98-rearranged acute leukemia.
Not a fit: Patients with other types of leukemia or those who do not have NUP98 rearrangements may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective therapies for children suffering from aggressive forms of leukemia.
How similar studies have performed: Other research has shown promise in targeting genetic alterations in leukemia, suggesting that this approach could lead to significant advancements in treatment.
Where this research is happening
Memphis, United States
- St. Jude Children's Research Hospital — Memphis, United States (Active)
Researchers
- Principal investigator: Mullighan, Charles G. — St. Jude Children's Research Hospital
- Study coordinator: Mullighan, Charles G.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.