Investigating a specific genetic alteration in childhood leukemia
Official title: Experimental and preclinical modeling of NUP98-rearranged acute leukemia
Funded at St. Jude Children's Research Hospital · NIH-10228882 · Data updated 2026-11-12
This study is looking at how certain proteins linked to leukemia in kids and teens work, so researchers can find new ways to treat this tough disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Jude Children's Research Hospital NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project start | September 19, 2019 |
| Project end | August 31, 2025 |
| Funding year | 2020 |
| Award (this year) | $159,625 |
| NIH project number | 3U54CA243124-01S1 |
| Project ID | NIH-10228882 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children and adolescents diagnosed with NUP98-rearranged acute leukemia.
✕Less likely to help
Patients with other types of leukemia or those who do not have NUP98 rearrangements may not benefit from this research.
What this research studies
This research focuses on understanding the role of NUP98 fusion oncoproteins in high-risk myeloid leukemias affecting children and adolescents. By developing and studying human and mouse models, the team aims to uncover the molecular mechanisms behind these leukemias and identify potential vulnerabilities that could be targeted with new therapies. The project involves a collaborative effort among experts in various fields, including genomics and drug development, to create innovative treatment strategies for these aggressive cancers.
Why it matters
Potential benefit: If successful, this research could lead to more effective therapies for children suffering from aggressive forms of leukemia.
How similar studies have gone: Other research has shown promise in targeting genetic alterations in leukemia, suggesting that this approach could lead to significant advancements in treatment.
Where this research is happening
-
St. Jude Children's Research Hospital
Memphis, United States Active
Researchers
- Principal investigator: Mullighan, Charles G. — St. Jude Children's Research Hospital
- Study coordinator: Mullighan, Charles G.
Related research
Other NIH-funded projects on the same topics.
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Investigating a specific type of leukemia in children caused by genetic changes.
This study is looking at how certain proteins linked to leukemia affect kids and teens with high-risk blood cancers, and the researchers hope to find new ways to treat these conditions by learning more about how the disease works.
-
Reducing leukemia disparities in Latino children and teens
A large, multi-project effort aims to understand why Latino children with acute lymphoblastic leukemia have worse outcomes and how to reduce those gaps.
-
Genomic advances to improve outcomes in high-risk acute leukemia
A physician-scientist team is studying the genetic drivers of pediatric acute leukemia to find new ways to diagnose and treat it, with the goal of improving cure rates for kids.
-
Understanding and Targeting Extramedullary Acute Leukemia
A clinician-research team is studying myeloid sarcoma, a form of AML that forms solid tumors outside the bone marrow, to develop new treatments for patients.
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Diversifying acute leukemia trial enrollment through multilevel approach
Aiming to broaden participation in acute leukemia trials by testing a multi-layer plan that addresses barriers for adults with AML.
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Blocking menin to treat acute leukemias with high HOX gene activity
This work develops new drugs that block a protein called menin to help people with certain aggressive acute leukemias driven by HOX gene activation.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.