Understanding and treating a specific type of acute leukemia caused by NUP98 gene changes
Experimental and preclinical modeling of NUP98-rearranged acute leukemia
This study is looking at a tough type of leukemia called NUP98-rearranged acute leukemia to find better ways to understand and treat it, using new techniques to see how certain genetic changes cause the disease and what new treatments might help patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Jude Children's Research Hospital NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project ID | NIH-10829603 on NIH RePORTER |
What this research studies
This research focuses on NUP98-rearranged acute leukemia, a high-risk form of leukemia. The team aims to develop better experimental models to study this disease and identify how specific genetic changes lead to leukemia. By using advanced techniques like cell barcoding and single-cell sequencing, they will explore the biology of the disease and potential new therapies. This work is designed to improve understanding and treatment options for patients with this type of leukemia.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with NUP98-rearranged acute leukemia.
Not a fit: Patients with other types of leukemia or those without NUP98 rearrangements may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients with NUP98-rearranged acute leukemia.
How similar studies have performed: Previous research has shown promise in using similar genetic and modeling approaches to understand and treat various forms of leukemia.
Where this research is happening
Memphis, United States
- St. Jude Children's Research Hospital — Memphis, United States (Active)
Researchers
- Principal investigator: Mullighan, Charles G. — St. Jude Children's Research Hospital
- Study coordinator: Mullighan, Charles G.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.