Understanding how changes in DNA structure affect treatment outcomes in children with leukemia
Remodeling of 3D chromatin in B cell acute leukemia and its impact on clinical outcome
This study is looking at how changes in the way DNA is organized can affect how well treatments work for kids with B cell acute leukemia, with the hope of finding better ways to help them feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11082275 on NIH RePORTER |
What this research studies
This research investigates the role of chromatin remodeling in B cell acute leukemia, particularly focusing on how changes in DNA structure can influence treatment responses and clinical outcomes. By utilizing advanced techniques to analyze the organization of chromatin, the study aims to uncover the mechanisms behind leukemia initiation and resistance to therapy. The findings could lead to the development of more targeted and effective therapies for children suffering from this condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are children diagnosed with acute lymphoblastic leukemia, particularly those who may not be responding well to current therapies.
Not a fit: Patients with other types of leukemia or those who are not diagnosed with acute lymphoblastic leukemia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies that are more effective and less burdensome for children with acute lymphoblastic leukemia.
How similar studies have performed: While the approach of studying chromatin remodeling in leukemia is relatively novel, there have been successful studies in related areas that suggest potential for impactful findings.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Carroll, William L. — New York University School of Medicine
- Study coordinator: Carroll, William L.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.