Understanding how changes in DNA structure affect treatment outcomes in children with leukemia
Official title: Remodeling of 3D chromatin in B cell acute leukemia and its impact on clinical outcome
Funded at New York University School of Medicine · NIH-11082275 · Data updated 2026-11-12
This study is looking at how changes in the way DNA is organized can affect how well treatments work for kids with B cell acute leukemia, with the hope of finding better ways to help them feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | April 1, 2021 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $430,442 |
| NIH project number | 5R01CA260028-05 |
| Project ID | NIH-11082275 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children diagnosed with acute lymphoblastic leukemia, particularly those who may not be responding well to current therapies.
✕Less likely to help
Patients with other types of leukemia or those who are not diagnosed with acute lymphoblastic leukemia may not benefit from this research.
What this research studies
This research investigates the role of chromatin remodeling in B cell acute leukemia, particularly focusing on how changes in DNA structure can influence treatment responses and clinical outcomes. By utilizing advanced techniques to analyze the organization of chromatin, the study aims to uncover the mechanisms behind leukemia initiation and resistance to therapy. The findings could lead to the development of more targeted and effective therapies for children suffering from this condition.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies that are more effective and less burdensome for children with acute lymphoblastic leukemia.
How similar studies have gone: While the approach of studying chromatin remodeling in leukemia is relatively novel, there have been successful studies in related areas that suggest potential for impactful findings.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Carroll, William L. — New York University School of Medicine
- Study coordinator: Carroll, William L.
Related research
Other NIH-funded projects on the same topics.
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Investigating a specific type of leukemia in children caused by genetic changes.
This study is looking at how certain proteins linked to leukemia affect kids and teens with high-risk blood cancers, and the researchers hope to find new ways to treat these conditions by learning more about how the disease works.
-
Reducing leukemia disparities in Latino children and teens
A large, multi-project effort aims to understand why Latino children with acute lymphoblastic leukemia have worse outcomes and how to reduce those gaps.
-
Genomic advances to improve outcomes in high-risk acute leukemia
A physician-scientist team is studying the genetic drivers of pediatric acute leukemia to find new ways to diagnose and treat it, with the goal of improving cure rates for kids.
-
Understanding and Targeting Extramedullary Acute Leukemia
A clinician-research team is studying myeloid sarcoma, a form of AML that forms solid tumors outside the bone marrow, to develop new treatments for patients.
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Diversifying acute leukemia trial enrollment through multilevel approach
Aiming to broaden participation in acute leukemia trials by testing a multi-layer plan that addresses barriers for adults with AML.
-
Blocking menin to treat acute leukemias with high HOX gene activity
This work develops new drugs that block a protein called menin to help people with certain aggressive acute leukemias driven by HOX gene activation.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.