Monitoring blood markers in elderly patients with acute leukemia after chemotherapy
Monitoring Circulating Tumor DNA After Chemotherapy in Elderly Patients With Acute Leukemia
This study is testing if measuring certain blood markers can help doctors understand how well chemotherapy is working for older patients with acute leukemia.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 200 (estimated) |
| Ages | 60 Years to 100 Years |
| Sex | All |
| Sponsor | Navy General Hospital, Beijing Academic / other |
| Drugs / interventions | Chemotherapy |
| Locations | 1 site (Beijing) |
| Trial ID | NCT04157569 on ClinicalTrials.gov |
What this trial studies
This observational study aims to monitor circulating tumor DNA (CtDNA) levels in elderly patients diagnosed with acute leukemia following chemotherapy treatment. Utilizing the droplet digital PCR (ddPCR) method, the study will quantify the mutant allele frequency (MAF) in peripheral blood plasma to assess the clinical significance of CtDNA in this patient population. The findings may provide insights into treatment efficacy and disease progression in elderly patients.
Who should consider this trial
Good fit: Ideal candidates for this study are elderly male patients aged 60 years and older who have been diagnosed with acute leukemia.
Not a fit: Patients who are pregnant, HIV positive, or aged 100 years and older may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance the understanding of treatment responses in elderly acute leukemia patients, potentially leading to improved monitoring and management strategies.
How similar studies have performed: While the use of CtDNA monitoring in cancer treatment is gaining traction, this specific approach in elderly acute leukemia patients is relatively novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Written informed consent * Male * not pregnant female * patients \>=60 years old * Diagnosis of acute leukemia Exclusion Criteria: * Pregnancy * HIV positive * patients \>=100 years old
Where this trial is running
Beijing
- Navy General Hospital — Beijing, China (Recruiting)
Study contacts
- Study coordinator: Liren Qian, MD
- Email: qlr2007@126.com
- Phone: +861066957676
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.