Improving Access to Acute Leukemia Clinical Trials for Diverse Patients
Official title: Diversifying Acute Leukemia Clinical Trial Enrollment Through Multilevel Intervention
Funded at Dana-Farber Cancer Inst · NIH-11109703 · Data updated 2026-11-12
This effort aims to help more Black and Hispanic adults with acute leukemia join clinical trials, ensuring everyone has a fair chance at new treatments.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dana-Farber Cancer Inst NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | July 1, 2022 |
| Project end | June 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $255,716 |
| NIH project number | 5K08CA273043-04 |
| Project ID | NIH-11109703 on NIH RePORTER |
Who could benefit from this research
✓Could help
This work is relevant to adult patients, aged 21 and older, diagnosed with acute myeloid or lymphoblastic leukemia, particularly those from Black and Hispanic communities.
✕Less likely to help
Patients who are not seeking participation in acute leukemia clinical trials or who do not face barriers to enrollment may not directly benefit from this specific intervention.
What this research studies
We know that clinical trials for aggressive blood cancers like acute myeloid and lymphoblastic leukemia often don't include enough Black and Hispanic adults, which can limit who benefits from new therapies. This project looks at why these differences exist, including how trials are designed, how doctors talk about them, and patient concerns. We plan to create new ways to review trial plans, empower healthcare providers, and address patient hesitations to make sure more people can access these important treatment options.
Why it matters
Potential benefit: If successful, this work could lead to more equitable access to advanced treatments and high-quality care for diverse patients with acute leukemia.
How similar studies have gone: While disparities in clinical trial enrollment are recognized, this project proposes a novel, multilevel intervention specifically tailored to the unique care patterns of acute leukemia.
Where this research is happening
-
Dana-Farber Cancer Inst
Boston, United States Active
Researchers
- Principal investigator: Hantel, Andrew — Dana-Farber Cancer Inst
- Study coordinator: Hantel, Andrew
Related research
Other NIH-funded projects on the same topics.
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Investigating a specific type of leukemia in children caused by genetic changes.
This study is looking at how certain proteins linked to leukemia affect kids and teens with high-risk blood cancers, and the researchers hope to find new ways to treat these conditions by learning more about how the disease works.
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Reducing leukemia disparities in Latino children and teens
A large, multi-project effort aims to understand why Latino children with acute lymphoblastic leukemia have worse outcomes and how to reduce those gaps.
-
Genomic advances to improve outcomes in high-risk acute leukemia
A physician-scientist team is studying the genetic drivers of pediatric acute leukemia to find new ways to diagnose and treat it, with the goal of improving cure rates for kids.
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Understanding and Targeting Extramedullary Acute Leukemia
A clinician-research team is studying myeloid sarcoma, a form of AML that forms solid tumors outside the bone marrow, to develop new treatments for patients.
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Diversifying acute leukemia trial enrollment through multilevel approach
Aiming to broaden participation in acute leukemia trials by testing a multi-layer plan that addresses barriers for adults with AML.
-
Blocking menin to treat acute leukemias with high HOX gene activity
This work develops new drugs that block a protein called menin to help people with certain aggressive acute leukemias driven by HOX gene activation.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.