Understanding how 3D chromatin changes in acute leukemia
Official title: Dynamic 3D chromatin remodeling in acute leukemia - Resubmission - 1
Funded at New York University School of Medicine · NIH-11059139 · Data updated 2026-11-12
This study is looking at how changes in DNA structure in people with acute leukemia can affect how genes work and may lead to challenges like drug resistance and relapse, with the hope of finding new ways to treat the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | April 1, 2021 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $617,534 |
| NIH project number | 5R01CA252239-05 |
| Project ID | NIH-11059139 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0-11 years diagnosed with acute leukemia.
✕Less likely to help
Patients with chronic forms of leukemia or those outside the specified age range may not benefit from this research.
What this research studies
This research investigates the structural changes in DNA that occur in acute leukemia, particularly focusing on how these changes affect gene regulation and contribute to cancer progression. By utilizing advanced techniques to analyze patient samples, the study aims to identify specific disruptions in chromatin organization that may lead to drug resistance and relapse in leukemia. The approach combines innovative 3C-based methods with insights from chromatin architecture to explore the relationship between chromatin structure and cancer biology. This research could provide valuable information on the mechanisms driving leukemia and potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for acute leukemia by identifying new targets for therapy.
How similar studies have gone: Other research has shown promising results in understanding chromatin dynamics in cancer, suggesting that this approach could yield significant insights.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Tsirigos, Aristotelis — New York University School of Medicine
- Study coordinator: Tsirigos, Aristotelis
Related research
Other NIH-funded projects on the same topics.
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This work develops new drugs that block a protein called menin to help people with certain aggressive acute leukemias driven by HOX gene activation.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.