Brain imaging in young patients with acute leukemia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to investigate the neurocognitive effects of chemotherapy in children, adolescents, and young adults diagnosed with acute leukemia by utilizing a brain imaging technique called Magnetic Resonance Fingerprinting (MRF). Participants will undergo MRF scans at diagnosis and at various points during and after their chemotherapy treatment to assess changes in brain matter. The goal is to identify those at risk for cognitive impairments resulting from chemotherapy and to develop strategies to mitigate these effects, thereby improving long-term quality of life for survivors.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age range: 0 - 30 years
* Participants from University Hospitals Rainbow Babies \& Children's Hospital, UH Seidman Cancer Center, and participants referred from outside facilities diagnosed with acute leukemia.
* Meets diagnostic criteria for acute leukemia including acute lymphocytic leukemia (ALL), acute myeloid leukemia (AML) and myeloproliferative neoplasm/leukemia.
* Participants must have the ability to understand and the willingness to sign a written informed consent document. Participants who are 14 years and older must have the ability to understand and the willingness to sign a written informed consent document. Participants who are between the ages of 7 to 13 will be given an information sheet that explains the study to them. The information sheet may be used for study participants between the ages of 14-17 if it would better inform the child about the nature and procedures that will undergo as a participant in the study.

Exclusion Criteria:

* Individuals that are \>2 weeks into the induction chemotherapy for acute leukemia.
* Individuals with either a heart pacemaker, heart defibrillator, metal in the eye, some types of metal elsewhere within the body such as certain surgical clips for aneurysms in the head, heart valve prostheses, electrodes, some other implanted devices, or any other MRI contraindication

Where it's running

• University Hospitals Cleveland Medical Center, Rainbow Babies & Children's Hospital, Case Comprehensive Cancer Center
  Cleveland, Ohio, United States Recruiting

Study contacts

• Principal investigator: Anupam Verma, MD — University Hospitals Cleveland Medical Center, Rainbow Babies & Children's Hospital, Case Comprehensive Cancer Center
• Study coordinator: Anupam Verma, MD
• Email: Anupam.verma@uhhospitals.org
• Phone: 216-844-1404

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.