Turning genetic discoveries into better care for high-risk acute leukemia
Translating genomic discoveries to improved outcomes for high risk acute leukemia
['FUNDING_OTHER'] · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · NIH-11178425
Researchers are using genetic information to find new tests and targeted treatments for children and young people with high‑risk acute leukemia.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (nih funded) |
| Locations | 1 site (MEMPHIS, UNITED STATES) |
| Trial ID | NIH-11178425 on ClinicalTrials.gov |
What this research studies
You would be part of research that looks at the DNA changes that cause aggressive acute leukemia and make it hard to treat. Scientists compare patient samples with laboratory models to understand how specific gene changes (like enhancer errors, BCL11B problems, LMO2 activation, and STAG2 loss) and abnormal protein behavior drive the disease. They are testing new approaches, including drugs that mark disease-causing proteins for destruction, to target drivers that current treatments cannot. The goal is to turn these findings into better diagnostics and medicines that raise cure rates for young patients with high‑risk leukemia.
Who could benefit from this research
Good fit: Ideal candidates are children and young adults with newly diagnosed or relapsed high‑risk acute leukemia who could provide samples or join future targeted therapy trials.
Not a fit: Patients with low‑risk leukemia subtypes or unrelated medical conditions are unlikely to receive direct benefit from this specific program.
Why it matters
Potential benefit: If successful, this work could produce new diagnostic tests and targeted therapies that improve cure rates for patients with high‑risk acute leukemia.
How similar studies have performed: Prior studies have identified leukemia subtypes and shown early promise for targeted protein degradation, but many approaches remain experimental and not yet proven in patients.
Where this research is happening
MEMPHIS, UNITED STATES
- ST. JUDE CHILDREN'S RESEARCH HOSPITAL — MEMPHIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MULLIGHAN, CHARLES G — ST. JUDE CHILDREN'S RESEARCH HOSPITAL
- Study coordinator: MULLIGHAN, CHARLES G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancer Cause, Cancer Etiology, Cancers