Investigating how mRNA stability affects blood cell development and leukemia
mRNA stability and its impact on hematopoiesis and acute leukemia
['FUNDING_R01'] · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · NIH-11003300
This study is looking at how certain proteins affect blood cell development in people with acute myeloid leukemia (AML), with the goal of finding new treatments that could help both kids and adults with this type of cancer.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NEW YORK UNIVERSITY SCHOOL OF MEDICINE (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11003300 on ClinicalTrials.gov |
What this research studies
This research focuses on acute myeloid leukemia (AML), a type of blood cancer with low survival rates and limited treatment options. The team is using advanced techniques like CRISPR/Cas9 to identify how specific RNA binding proteins, particularly ZFP36L2, influence the stability of mRNA and its role in blood cell differentiation. By understanding these mechanisms, the research aims to develop new therapeutic strategies that could improve outcomes for patients with AML. The study involves both adult and pediatric populations, highlighting the importance of targeted therapies for different age groups.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with acute myeloid leukemia, both adults and children.
Not a fit: Patients with other types of leukemia or blood disorders unrelated to acute myeloid leukemia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve survival rates for patients with acute myeloid leukemia.
How similar studies have performed: Previous research has shown promise in using differentiation therapies for specific subtypes of AML, indicating potential for success with this novel approach.
Where this research is happening
NEW YORK, UNITED STATES
- NEW YORK UNIVERSITY SCHOOL OF MEDICINE — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: AIFANTIS, IANNIS — NEW YORK UNIVERSITY SCHOOL OF MEDICINE
- Study coordinator: AIFANTIS, IANNIS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.