Investigating how mRNA stability affects blood cell development and leukemia
Official title: mRNA stability and its impact on hematopoiesis and acute leukemia
Funded at New York University School of Medicine · NIH-11003300 · Data updated 2026-11-12
This study is looking at how certain proteins affect blood cell development in people with acute myeloid leukemia (AML), with the goal of finding new treatments that could help both kids and adults with this type of cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | January 1, 2022 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $540,134 |
| NIH project number | 5R01CA266212-04 |
| Project ID | NIH-11003300 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with acute myeloid leukemia, both adults and children.
✕Less likely to help
Patients with other types of leukemia or blood disorders unrelated to acute myeloid leukemia may not benefit from this research.
What this research studies
This research focuses on acute myeloid leukemia (AML), a type of blood cancer with low survival rates and limited treatment options. The team is using advanced techniques like CRISPR/Cas9 to identify how specific RNA binding proteins, particularly ZFP36L2, influence the stability of mRNA and its role in blood cell differentiation. By understanding these mechanisms, the research aims to develop new therapeutic strategies that could improve outcomes for patients with AML. The study involves both adult and pediatric populations, highlighting the importance of targeted therapies for different age groups.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve survival rates for patients with acute myeloid leukemia.
How similar studies have gone: Previous research has shown promise in using differentiation therapies for specific subtypes of AML, indicating potential for success with this novel approach.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Aifantis, Iannis — New York University School of Medicine
- Study coordinator: Aifantis, Iannis
Related research
Other NIH-funded projects on the same topics.
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Investigating a specific type of leukemia in children caused by genetic changes.
This study is looking at how certain proteins linked to leukemia affect kids and teens with high-risk blood cancers, and the researchers hope to find new ways to treat these conditions by learning more about how the disease works.
-
Reducing leukemia disparities in Latino children and teens
A large, multi-project effort aims to understand why Latino children with acute lymphoblastic leukemia have worse outcomes and how to reduce those gaps.
-
Genomic advances to improve outcomes in high-risk acute leukemia
A physician-scientist team is studying the genetic drivers of pediatric acute leukemia to find new ways to diagnose and treat it, with the goal of improving cure rates for kids.
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Understanding and Targeting Extramedullary Acute Leukemia
A clinician-research team is studying myeloid sarcoma, a form of AML that forms solid tumors outside the bone marrow, to develop new treatments for patients.
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Diversifying acute leukemia trial enrollment through multilevel approach
Aiming to broaden participation in acute leukemia trials by testing a multi-layer plan that addresses barriers for adults with AML.
-
Blocking menin to treat acute leukemias with high HOX gene activity
This work develops new drugs that block a protein called menin to help people with certain aggressive acute leukemias driven by HOX gene activation.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.