Predicting neurotoxicity from methotrexate in children with leukemia
Official title: A Systems Epidemiology Approach for Predicting Methotrexate Neurotoxicity in Pediatric Acute Leukemia
Funded at Baylor College of Medicine · NIH-11063802 · Data updated 2026-11-12
This study is looking at how certain biological factors might help us understand why some children, especially Latino kids, may experience more side effects from their leukemia treatment with methotrexate, so we can find ways to improve their care and outcomes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | April 21, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $608,609 |
| NIH project number | 5R01CA272981-03 |
| Project ID | NIH-11063802 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0-11 years diagnosed with acute lymphoblastic leukemia, particularly those from Latino backgrounds.
✕Less likely to help
Patients with other types of leukemia or those outside the specified age range may not benefit from this research.
What this research studies
This research investigates how certain biological factors can predict the risk of neurotoxicity in children undergoing treatment for acute lymphoblastic leukemia (ALL) with methotrexate. The study focuses on understanding ethnic disparities, particularly among Latino children, who may experience higher rates of treatment-related side effects. By identifying specific host factors that contribute to these toxicities, the research aims to improve treatment outcomes and reduce disparities in survival rates. Patients will be monitored for neurological symptoms that may indicate increased risk, allowing for better management of their treatment.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment protocols that minimize neurotoxicity and enhance survival rates for children with leukemia.
How similar studies have gone: Previous research has shown that understanding ethnic-specific biological factors can lead to significant improvements in treatment outcomes, suggesting this approach has potential for success.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Brown, Austin L — Baylor College of Medicine
- Study coordinator: Brown, Austin L
Related research
Other NIH-funded projects on the same topics.
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Investigating a specific type of leukemia in children caused by genetic changes.
This study is looking at how certain proteins linked to leukemia affect kids and teens with high-risk blood cancers, and the researchers hope to find new ways to treat these conditions by learning more about how the disease works.
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Reducing leukemia disparities in Latino children and teens
A large, multi-project effort aims to understand why Latino children with acute lymphoblastic leukemia have worse outcomes and how to reduce those gaps.
-
Genomic advances to improve outcomes in high-risk acute leukemia
A physician-scientist team is studying the genetic drivers of pediatric acute leukemia to find new ways to diagnose and treat it, with the goal of improving cure rates for kids.
-
Understanding and Targeting Extramedullary Acute Leukemia
A clinician-research team is studying myeloid sarcoma, a form of AML that forms solid tumors outside the bone marrow, to develop new treatments for patients.
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Diversifying acute leukemia trial enrollment through multilevel approach
Aiming to broaden participation in acute leukemia trials by testing a multi-layer plan that addresses barriers for adults with AML.
-
Blocking menin to treat acute leukemias with high HOX gene activity
This work develops new drugs that block a protein called menin to help people with certain aggressive acute leukemias driven by HOX gene activation.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.