Understanding how specific sugars on leukemia cells affect blood cancer development
Official title: Analysis of E-selectin Ligands of Human Acute Leukemia Cells and their Biology in Leukemogenesis
Funded at Florida International University · NIH-10646189 · Data updated 2026-11-12
This study is looking at a special sugar on leukemia cells to see how it helps these cells stick to blood vessels, which could lead to new ways to treat blood cancers like leukemia.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Florida International University NIH-funded |
| Lab location | 1 site (Miami, United States) |
| Project start | July 17, 2019 |
| Project end | June 30, 2025 |
| Funding year | 2023 |
| Award (this year) | $601,611 |
| NIH project number | 5U01CA225730-05 |
| Project ID | NIH-10646189 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with acute leukemia who may be eligible for new treatment approaches.
✕Less likely to help
Patients with chronic forms of leukemia or those who are not currently undergoing treatment may not benefit from this research.
What this research studies
This research investigates the role of a specific sugar structure, known as sialylated Lewis X (sLeX), on the surface of leukemia cells and how it influences the development of blood cancers. By examining the enzymes that produce this sugar and its interaction with blood vessel cells, the study aims to uncover mechanisms that could lead to better treatments for leukemia. The research involves analyzing how these sugar structures help leukemia cells adhere to blood vessels, which is crucial for their growth and spread. Patients may benefit from insights that could lead to new therapeutic strategies targeting these interactions.
Why it matters
Potential benefit: If successful, this research could lead to novel treatments that inhibit leukemia cell growth and improve patient outcomes.
How similar studies have gone: Previous research has shown promising results in targeting similar cellular interactions in other types of cancers, indicating potential for success in this area as well.
Where this research is happening
-
Florida International University
Miami, United States Active
Researchers
- Principal investigator: Sackstein, Robert — Florida International University
- Study coordinator: Sackstein, Robert
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.