Improving diversity in clinical trials for acute leukemia treatments
Official title: Diversifying Acute Leukemia Clinical Trial Enrollment Through Multilevel Intervention
Funded at Dana-Farber Cancer Inst · NIH-10874675 · Data updated 2026-11-12
This study is looking at why fewer Black and Hispanic adults with acute leukemia join clinical trials and aims to find ways to make it easier for everyone to participate, so that all patients can access the best treatments available.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dana-Farber Cancer Inst NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | July 1, 2022 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $254,592 |
| NIH project number | 5K08CA273043-03 |
| Project ID | NIH-10874675 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are Black and Hispanic adults diagnosed with acute myeloid leukemia or acute lymphoblastic leukemia.
✕Less likely to help
Patients who do not have acute leukemia or belong to racial and ethnic groups that are already well-represented in clinical trials may not benefit from this research.
What this research studies
This research aims to address the significant disparities in clinical trial enrollment among different racial and ethnic groups, particularly focusing on Black and Hispanic adults with acute leukemia. By analyzing existing trial designs and patient behaviors, the study seeks to identify barriers that prevent diverse participation. It will implement a multilevel intervention strategy that includes reviewing trial protocols and integrating data from cancer registries and electronic health records to enhance enrollment diversity. The ultimate goal is to ensure equitable access to innovative therapies and high-quality care for all patients affected by acute leukemia.
Why it matters
Potential benefit: If successful, this research could lead to more equitable access to clinical trials and improved treatment outcomes for diverse patient populations with acute leukemia.
How similar studies have gone: Previous research has shown that targeted interventions can successfully improve diversity in clinical trial enrollment, making this approach promising yet innovative.
Where this research is happening
-
Dana-Farber Cancer Inst
Boston, United States Active
Researchers
- Principal investigator: Hantel, Andrew — Dana-Farber Cancer Inst
- Study coordinator: Hantel, Andrew
Related research
Other NIH-funded projects on the same topics.
-
Investigating a specific type of leukemia in children caused by genetic changes.
This study is looking at how certain proteins linked to leukemia affect kids and teens with high-risk blood cancers, and the researchers hope to find new ways to treat these conditions by learning more about how the disease works.
-
Reducing leukemia disparities in Latino children and teens
A large, multi-project effort aims to understand why Latino children with acute lymphoblastic leukemia have worse outcomes and how to reduce those gaps.
-
Genomic advances to improve outcomes in high-risk acute leukemia
A physician-scientist team is studying the genetic drivers of pediatric acute leukemia to find new ways to diagnose and treat it, with the goal of improving cure rates for kids.
-
Understanding and Targeting Extramedullary Acute Leukemia
A clinician-research team is studying myeloid sarcoma, a form of AML that forms solid tumors outside the bone marrow, to develop new treatments for patients.
-
Diversifying acute leukemia trial enrollment through multilevel approach
Aiming to broaden participation in acute leukemia trials by testing a multi-layer plan that addresses barriers for adults with AML.
-
Blocking menin to treat acute leukemias with high HOX gene activity
This work develops new drugs that block a protein called menin to help people with certain aggressive acute leukemias driven by HOX gene activation.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.