Using CD45RA Depleted Stem Cells to Improve Immune Recovery After Transplant

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the use of CD45RA depleted peripheral stem cells to enhance immune reconstitution in patients undergoing hematopoietic stem cell transplant (HSCT) for acute leukemias. The approach aims to reduce the risk of graft versus host disease (GVHD) while also addressing the slow recovery of the immune system, which increases susceptibility to infections. By adding back these specific donor cells after T cell depletion, the study seeks to improve patient outcomes and decrease infection rates. The trial is conducted at a single institution, focusing on a specific patient population with high-risk acute leukemias.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age: Patients \<25 years.
2. First allogeneic HSCT only.
3. Disease eligibility: Acute leukemias at high risk for relapse including positive minimal residual disease at end consolidation, high risk cytogenetics, or relapse. Hematologic malignancies including: acute myeloid leukemia, myelodysplastic syndromes, acute lymphoblastic leukemia, mixed lineage or bi-phenotypic leukemia, lymphoblastic or Burkitts, juvenile myelomonocytic leukemia
4. Evaluation of organ and infectious status as per our Bone Marrow Transplant standard operating procedure (BMT SOP).
5. Signed consent by parent/guardian or able to give consent if \>18 years.

Exclusion Criteria:

1. Patients who do not meet institutional disease, organ or infectious criteria
2. No suitable donor available for mobilized peripheral stem cells
3. Patients with genetic disorders including Fanconi anemia, Kostmann syndrome, dyskeratosis congenital or other DNA repair defects.
4. Patients with Hodgkin lymphoma or non-Burkitts, non-lymphoblastic lymphoma
5. Pregnant Participants

Donor selection and eligibility

1. Unrelated donor meets National Marrow Donor Program criteria for donation
2. HLA testing/matching
3. Donor must be willing to undergo granulocyte colony stimulating factor (GCSF) mobilization and peripheral blood stem cell collection

Where it's running

• Children's Hospital of Philadelphia
  Philadelphia, Pennsylvania, United States Recruiting

Study contacts

• Principal investigator: Timothy Olson, MD, PhD — Children's Hospital of Philadelphia
• Study coordinator: Megan Atkinson
• Email: cttsbmtintake@chop.edu
• Phone: 215-590-2820

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Comparing two conditioning regimens for haploidentical stem cell transplantation

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• Depleting specific immune cells in stem cell transplants for blood cancers

  This study is testing if removing certain immune cells during stem cell transplants can help children and young adults with blood cancers have better outcomes and fewer complications.

  Recruiting Phase 2 University of Florida · Gainesville, Florida · NCT05800210

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.