Investigating heart issues in COPD patients during hospital stays
Prospective Observational Study of Myocardial Stunning in Patients Hospitalized for Exacerbation of Chronic Obstructive Pulmonary Disease
Sahlgrenska University Hospital · NCT06597331
This study is trying to see if sudden worsening of COPD can cause heart problems in hospitalized patients and how it affects their recovery.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 200 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Sahlgrenska University Hospital (other) |
| Locations | 1 site (Gothenburg, Region Västra Götaland) |
| Trial ID | NCT06597331 on ClinicalTrials.gov |
What this trial studies
This observational study aims to explore how acute exacerbations of chronic obstructive pulmonary disease (AE-COPD) may trigger Takotsubo-stunning in hospitalized patients and the subsequent impact on their health outcomes. It will assess the incidence of Takotsubo-stunning among these patients and compare the risk of in-hospital acute heart failure between those with and without this condition. The study will involve adult patients admitted for AE-COPD at Sahlgrenska University Hospital in Gothenburg, Sweden, and will collect data within 72 hours of their admission.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older who are hospitalized for acute exacerbations of chronic obstructive pulmonary disease.
Not a fit: Patients with a history of acute myocardial infarction or significant pre-existing heart conditions may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve the diagnosis and management of heart complications in COPD patients, potentially leading to better patient outcomes.
How similar studies have performed: While the specific approach of this study may be novel, there is existing literature suggesting a link between COPD exacerbations and Takotsubo syndrome, indicating potential for meaningful insights.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patients (≥ 18 years old) admitted to hospital ward for AE-COPD * Inclusion within 72 hours of admission, * Written informed consent Exclusion Criteria: * Prior acute myocardial infarction or known pre-existing persistent regional wall motion abnormality or left ventricular dysfunction (left ventricular ejection fraction \[LVEF\] \<50%) * Expected inability to comply with the protocol (e.g. dementia)
Where this trial is running
Gothenburg, Region Västra Götaland
- Department of Emergency Medicine and Geriatrics, Sahlgrenska University Hospital/S — Gothenburg, Region Västra Götaland, Sweden (RECRUITING)
Study contacts
- Principal investigator: Rickard Zeijlon, M.D. PhD — Sahlgrenska University Hospital
- Study coordinator: Rickard Zeijlon, M.D. PhD
- Email: rickard.zeijlon@vgregion.se
- Phone: +46705821889
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Chronic Obstructive Pulmonary Disease, Takotsubo Cardiomyopathy, Acute Heart Failure, Takotsubo syndrome, COPD, Echocardiography, Screening, Trigger