Investigating heart issues in COPD patients during hospital stays
Official title: Prospective Observational Study of Myocardial Stunning in Patients Hospitalized for Exacerbation of Chronic Obstructive Pulmonary Disease
Run by Sahlgrenska University Hospital · NCT06597331 · Data updated 2026-11-12
This study is trying to see if sudden worsening of COPD can cause heart problems in hospitalized patients and how it affects their recovery.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 200 (estimated) |
| Sponsor | Sahlgrenska University Hospital Academic / other |
| Locations | 1 site (Gothenburg, Region Västra Götaland) |
| Status | Recruiting |
| Started | September 23, 2024 |
| Main results expected | December 31, 2027 |
| Study ends | September 1, 2028 |
| Registry record updated | September 17, 2026 |
| Trial ID | NCT06597331 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 and older who are hospitalized for acute exacerbations of chronic obstructive pulmonary disease.
✕Probably not a fit
Patients with a history of acute myocardial infarction or significant pre-existing heart conditions may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to explore how acute exacerbations of chronic obstructive pulmonary disease (AE-COPD) may trigger Takotsubo-stunning in hospitalized patients and the subsequent impact on their health outcomes. It will assess the incidence of Takotsubo-stunning among these patients and compare the risk of in-hospital acute heart failure between those with and without this condition. The study will involve adult patients admitted for AE-COPD at Sahlgrenska University Hospital in Gothenburg, Sweden, and will collect data within 72 hours of their admission.
Why it matters
Potential benefit: If successful, this study could improve the diagnosis and management of heart complications in COPD patients, potentially leading to better patient outcomes.
How similar studies have gone: While the specific approach of this study may be novel, there is existing literature suggesting a link between COPD exacerbations and Takotsubo syndrome, indicating potential for meaningful insights.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patients (≥ 18 years old) admitted to hospital ward for AE-COPD * Inclusion within 72 hours of admission, * Written informed consent Exclusion Criteria: * Prior acute myocardial infarction or known pre-existing persistent regional wall motion abnormality or left ventricular dysfunction (left ventricular ejection fraction \[LVEF\] \<50%) * Expected inability to comply with the protocol (e.g. dementia)
Where it's running
-
Department of Emergency Medicine and Geriatrics, Sahlgrenska University Hospital/S
Gothenburg, Region Västra Götaland, Sweden Recruiting
Study contacts
- Principal investigator: Rickard Zeijlon, M.D. PhD — Sahlgrenska University Hospital
- Study coordinator: Rickard Zeijlon, M.D. PhD
- Email: rickard.zeijlon@vgregion.se
- Phone: +46705821889
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Flutter therapy added to chest physiotherapy after CABG in COPD patients
This study tests whether adding Flutter therapy to standard chest physiotherapy helps post-CABG patients with mild-to-moderate COPD improve breathing more than chest physiotherapy alone.
-
TPB-based cadence exercise and breathing training for COPD patients
A TPB-based program tests whether breathing training, cadence-guided walking, or both can improve lung function, exercise capacity, and quality of life in adults with COPD.
-
See how dynamic chest X-rays relate to COPD patterns and progression risk
This study looks at existing dynamic chest radiography data to see if new imaging measurements can identify COPD patterns, gauge severity, and predict who may experience faster progression.
-
Personalized mobile app warnings to reduce COPD flares
A personalized mobile app tests whether providing temperature-related risk warnings and protective tips, in addition to usual COPD care, can lower COPD flare-ups over 12 months.
-
CLEAR model to predict when people with severe COPD can be taken off ventilatory support
This project will see if the CLEAR model can predict which adults with severe COPD on invasive or non‑invasive ventilation can be safely taken off ventilatory support.
-
Infusion of furosemide to see if a loading infusion helps remove fluid better in acute heart failure
This study tests whether giving furosemide as a continuous infusion with a loading dose is better at removing excess fluid than giving it as bolus injections in adults with acute heart failure.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.