Comparing two approaches to diuretic therapy for patients with acute heart failure in the emergency department
Official title: A Randomized Trial of Protocolized Diuretic Therapy Compared to Standard Care in Emergency Department Patients with Acute Heart Failure
Funded at Vanderbilt University Medical Center · NIH-10907749 · Data updated 2026-11-12
This study is looking at whether a special plan for using diuretics can help people with acute heart failure feel better and recover faster in the emergency department compared to the usual care they receive.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | September 1, 2021 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $818,597 |
| NIH project number | 5R33HL155810-04 |
| Project ID | NIH-10907749 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients admitted to the emergency department with acute heart failure who require diuretic therapy.
✕Less likely to help
Patients with chronic heart failure who are not experiencing acute symptoms may not benefit from this research.
What this research studies
This research investigates the effectiveness of a structured diuretic therapy protocol compared to standard care for patients experiencing acute heart failure in the emergency department. The study aims to personalize diuretic treatment to improve patient outcomes, particularly focusing on reducing fluid retention and improving symptoms like breathlessness. Patients will be randomly assigned to either the protocolized therapy or standard care, allowing researchers to assess which method leads to better recovery and fewer hospital readmissions. The approach includes monitoring patient responses to treatment and adjusting dosages as needed.
Why it matters
Potential benefit: If successful, this research could lead to improved management of acute heart failure, resulting in better symptom relief and reduced hospital readmissions for patients.
How similar studies have gone: Previous research has indicated that individualized treatment approaches can improve outcomes in heart failure patients, suggesting potential success for this protocolized method.
Where this research is happening
-
Vanderbilt University Medical Center
Nashville, United States Active
Researchers
- Principal investigator: Collins, Sean Patrick — Vanderbilt University Medical Center
- Study coordinator: Collins, Sean Patrick
Related research
Other NIH-funded projects on the same topics.
-
Using AI to monitor lung fluid in sudden (acute) heart failure in the ER
This project will use an AI-assisted lung ultrasound method to track lung congestion in people who come to the emergency department with acute heart failure.
-
Stepwise water‑pill (diuretic) plan versus usual care for people with acute heart failure in the emergency room
This project compares a step-by-step plan for giving water pills to usual care to help people with sudden worsening heart failure in the emergency room remove extra fluid and feel better sooner.
-
Using AI to monitor fluid buildup in patients with acute heart failure in emergency settings
This study is looking at how using a special ultrasound tool can help doctors better check for fluid buildup in the lungs of patients with acute heart failure in emergency rooms, so they can get the right treatment faster and leave the hospital feeling better.
-
Improving hospitalization decisions for emergency patients with heart failure
This study is looking at how to help doctors decide if patients with acute heart failure should be admitted to the hospital or can safely recover at home, by considering important factors about their health and personal situations.
-
Understanding changes in kidney function during acute heart failure
This study is looking into how heart failure affects kidney function, especially in veterans, to find specific markers that can help doctors understand the different reasons for kidney problems during heart failure, ultimately aiming to improve diagnosis and treatment for patients.
-
Improving how we diagnose acute heart failure
This study is working on a new way to help doctors more accurately diagnose acute heart failure in patients who come to the emergency room with symptoms like shortness of breath, so they can get the right treatment faster and feel better sooner.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.