Comparing two approaches to diuretic therapy for patients with acute heart failure in the emergency department
A Randomized Trial of Protocolized Diuretic Therapy Compared to Standard Care in Emergency Department Patients with Acute Heart Failure
This study is looking at whether a special plan for using diuretics can help people with acute heart failure feel better and recover faster in the emergency department compared to the usual care they receive.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-10907749 on NIH RePORTER |
What this research studies
This research investigates the effectiveness of a structured diuretic therapy protocol compared to standard care for patients experiencing acute heart failure in the emergency department. The study aims to personalize diuretic treatment to improve patient outcomes, particularly focusing on reducing fluid retention and improving symptoms like breathlessness. Patients will be randomly assigned to either the protocolized therapy or standard care, allowing researchers to assess which method leads to better recovery and fewer hospital readmissions. The approach includes monitoring patient responses to treatment and adjusting dosages as needed.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients admitted to the emergency department with acute heart failure who require diuretic therapy.
Not a fit: Patients with chronic heart failure who are not experiencing acute symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved management of acute heart failure, resulting in better symptom relief and reduced hospital readmissions for patients.
How similar studies have performed: Previous research has indicated that individualized treatment approaches can improve outcomes in heart failure patients, suggesting potential success for this protocolized method.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Collins, Sean Patrick — Vanderbilt University Medical Center
- Study coordinator: Collins, Sean Patrick
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.