Using lung ultrasound to guide treatment for acute heart failure

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effectiveness of a lung ultrasonography (LUS)-guided decongestion strategy for adults hospitalized with acute heart failure (AHF). It aims to determine if this approach can shorten hospital stays, reduce early readmissions, and improve patients' symptoms and quality of life compared to traditional physical examination methods. The study will be conducted as a multicenter, blinded, randomized controlled trial involving 222 participants, who will be assigned to either the LUS-guided strategy or standard care within 48 hours of hospital admission. The primary outcome will measure the number of days spent alive outside the hospital within 40 days of inclusion.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* ≥ 18 years old
* Planned or actual admission to intermediate care units, general internal medical or cardiology wards
* Diagnosis of congestive AHF on admission chart (primary or secondary diagnosis)
* Raised value of N terminal-pro-brain natriuretic peptide (≥1000 ng/l).

Key Exclusion Criteria:

* Known isolated right heart failure
* Systolic blood pressure \<90 mmHg, mean arterial pressure \<65 mmHg at the moment of inclusion
* The following conditions mimicking lung cardiogenic oedema on LUS if known at inclusion and documented: Interstitial lung disease, lung cancer or metastasis, acute respiratory distress syndrome, pulmonary contusion
* Known virologically confirmed SARS-CoV-2 pneumonia in the preceding 3 months
* Unwillingness to give consent
* Subjects who are pregnant or breastfeeding
* Hospitalisation for palliative care and probable end-life within 30 days

Where it's running

• Trois-Chêne Hospital, Geneva Univesity Hospitals
  Geneva, Canton of Geneva, Switzerland Recruiting
• Geneva University Hospitals
  Geneva, Canton of Geneva, Switzerland Recruiting
• Inselspital, Universitätspital
  Bern, Switzerland, Switzerland Recruiting
• Fribourg University Hospital
  Fribourg, Switzerland Recruiting
• Ospedale Civico, Ente Ospedaliero Cantonale
  Lugano, Switzerland Terminated

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.