Identifying triggers and progression of heart failure
Official title: Heart Failure-USB: Prediction and Progression
Run by University Hospital, Basel, Switzerland · NCT04000061 · Data updated 2026-11-12
This study looks at patients with heart failure to see what causes it and how it gets worse, while also testing if digoxin can help those whose heart failure is triggered by fast heartbeats.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 6000 (estimated) |
| Sponsor | University Hospital, Basel, Switzerland Academic / other |
| Locations | 1 site (Basel) |
| Status | Recruiting |
| Started | June 13, 2019 |
| Main results expected | April 4, 2027 |
| Study ends | April 4, 2027 |
| Registry record updated | September 22, 2026 |
| Trial ID | NCT04000061 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include patients who were hospitalized with acute coronary syndrome or acute heart failure.
✕Probably not a fit
Patients who have opted out of the scientific use of their clinical data will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to analyze data from patients hospitalized with acute coronary syndrome and acute heart failure between 2010 and 2023. It focuses on identifying the triggers for heart failure development and the factors driving its progression, as well as understanding the underlying cardiac disease phenotype. Additionally, a subgroup of patients will be evaluated for the efficacy and safety of digoxin in cases of acute heart failure triggered by tachyarrhythmia. The study utilizes medical chart reviews and data exports for comprehensive analysis.
Why it matters
Potential benefit: If successful, this study could enhance the prediction and management of heart failure, leading to improved patient outcomes.
How similar studies have gone: Other studies have shown success in identifying risk factors and predictors for heart failure, making this approach promising.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients hospitalized with a primary diagnosis of ACS * Patients hospitalized with a primary or secondary diagnosis of AHF Exclusion Criteria: * Existence of a documented statement of the patient against the scientific use of clinical data
Where it's running
-
Cardiology, University Hospital Basel
Basel, Switzerland Recruiting
Study contacts
- Principal investigator: Christian Müller, Prof. Dr. — Cardiology University Hospital Basel
- Study coordinator: Christian Müller, Prof. Dr.
- Email: Christian.mueller@usb.ch
- Phone: 0041 6132 86 549
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.