Clinical trial Recruiting at 1 site Observational Ages 18 and up

Identifying triggers and progression of heart failure

Official title: Heart Failure-USB: Prediction and Progression

Run by University Hospital, Basel, Switzerland · NCT04000061 · Data updated 2026-11-12

This study looks at patients with heart failure to see what causes it and how it gets worse, while also testing if digoxin can help those whose heart failure is triggered by fast heartbeats.

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment6000 (estimated)
SponsorUniversity Hospital, Basel, Switzerland
Academic / other
Locations1 site (Basel)
StatusRecruiting
StartedJune 13, 2019
Main results expectedApril 4, 2027
Study endsApril 4, 2027
Registry record updatedSeptember 22, 2026
Trial IDNCT04000061 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates include patients who were hospitalized with acute coronary syndrome or acute heart failure.

Probably not a fit

Patients who have opted out of the scientific use of their clinical data will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to analyze data from patients hospitalized with acute coronary syndrome and acute heart failure between 2010 and 2023. It focuses on identifying the triggers for heart failure development and the factors driving its progression, as well as understanding the underlying cardiac disease phenotype. Additionally, a subgroup of patients will be evaluated for the efficacy and safety of digoxin in cases of acute heart failure triggered by tachyarrhythmia. The study utilizes medical chart reviews and data exports for comprehensive analysis.

Why it matters

Potential benefit: If successful, this study could enhance the prediction and management of heart failure, leading to improved patient outcomes.

How similar studies have gone: Other studies have shown success in identifying risk factors and predictors for heart failure, making this approach promising.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Patients hospitalized with a primary diagnosis of ACS
* Patients hospitalized with a primary or secondary diagnosis of AHF

Exclusion Criteria:

* Existence of a documented statement of the patient against the scientific use of clinical data

Where it's running

  • Cardiology, University Hospital Basel
    Basel, Switzerland
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.