Evaluating congestion markers in patients with acute heart failure

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The AHF-CODE study is a prospective, non-randomized study focusing on patients hospitalized for acute heart failure with reduced ejection fraction. It aims to identify clinical, biological, and ultrasound markers of congestion at the time of discharge that may predict the risk of death or rehospitalization within three months. The study involves various assessments, including Doppler ultrasounds and blood sample analysis, to gather comprehensive data on the patients' conditions. This approach seeks to enhance understanding of heart failure management and improve patient outcomes post-discharge.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients hospitalised for acute heart failure.
* Patients with reduced ejection fraction (Ejection Fraction \<40%) or (40% ≤ Ejection Fraction \< 50)
* Patients considered clinically discharging from hospitalisation for acute heart failure.
* Age ≥18 years
* Patients having received complete information regarding the study design and having signed their informed consent form.
* Patient affiliated to or beneficiary of a social security scheme.

Exclusion Criteria:

* Comorbidity for which the life expectancy is ≤ 3 months
* Dialysis patient (peritoneal dialysis or hemodialysis) or patients with glomerular filtration rate \<15 ml/min/m2 at inclusion.
* History of lobectomy or pneumonectomy lung surgery
* Severe pulmonary or pleural pathology preventing reliable acquisition of lung ultrasound images: severe emphysema, chronic pleurisy, pulmonary fibrosis, etc.
* Pregnant woman, parturient or nursing mother
* Adult person subject to a legal protection measure (guardianship, curatorship, safeguard of justice) Adult person who is unable to give consent
* Person deprived of liberty by a judicial or administrative decision,
* Person subject to psychiatric care pursuant to Articles L. 3212-1 and L. 3213-1 of the Public Health Code.

Where it's running

• CHRU de Nancy
  Vandœuvre-lès-Nancy, France Recruiting

Study contacts

• Study coordinator: Nicolas GIRERD
• Email: n.girerd@chru-nancy.fr
• Phone: + 33 3 83 15 73 22

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.