Infusion of furosemide to see if a loading infusion helps remove fluid better in acute heart failure

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

INFUSE-AHF is a multicenter, open-label randomized trial in Denmark comparing two intravenous strategies for furosemide in adults with acute heart failure and fluid overload. Participants are assigned 1:1 to receive continuous infusion preceded by a loading dose or bolus injections three times daily, with treatment through Day 4 and follow-up up to 30 days after the first dose. The trial aims to determine which method achieves effective fluid removal more efficiently while considering safety and tolerability. It is designed as pragmatic to reflect real-world practice, enrolling patients during hospitalization who require IV furosemide for at least 3 days. Outcomes focus on diuretic effectiveness, weight change, and clinical status.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Clinical diagnosis of acute heart failure with volume overload
* At least 1 sign of volume overload
* Anticipated intravenous furosemide treatment for at least 3 days
* Age 18 years or older

Exclusion Criteria:

* Shock
* Patient requiring treatment with inotropes or vasopressors
* Current or planned use of renal replacement therapy or ultrafiltration
* Patient with a renal transplant
* Patients who are pregnant or breastfeeding
* Severe hypokalaemia, defined as potassium less than 2.5 mmol/L, or severe hyponatremia, defined as sodium less than 125 mmol/L
* Allergy to furosemide and its components

Where it's running

• Department of Medicine, Randers Regional Hospital
  Randers, Denmark Recruiting

Study contacts

• Study coordinator: Esben Merrild, MD
• Email: esbenmerrild@clin.au.dk
• Phone: +4522996026

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.