Condition
Heart Failure With Mildly Reduced Ejection Fraction clinical trials and research
As of November 12, 2026, Find a Trial lists 5 Heart Failure With Mildly Reduced Ejection Fraction clinical trials that are recruiting, at sites in 35 countries (most in France (2), Germany (2), Italy (2)). By phase: Phase 4 (2), Phase 3 (1). Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 5Clinical trials
- 35Countries
Newest Heart Failure With Mildly Reduced Ejection Fraction clinical trials
| Study | Phase | Where | Status | Registered |
|---|---|---|---|---|
| Intensive GDMT optimization for women after heart failure hospitalization | Phase 4 | San Donato Milanese, MILANO and 11 other locations | Recruiting | Dec 19, 2025 |
| Ablation versus medication for atrial fibrillation in people with preserved or mildly reduced heart function | — | Halifax, Nova Scotia and 3 other locations | Recruiting | Dec 9, 2025 |
| Maridebart cafraglutide for people with obesity and preserved or mildly reduced ejection fraction heart failure | Phase 3 | Birmingham, Alabama and 685 other locations | Recruiting | Jun 25, 2025 |
| Using blood samples to identify heart failure risks in diabetes patients | — | Bron | Recruiting | Dec 15, 2022 |
| Catheter ablation for atrial fibrillation in heart failure patients | Phase 4 | Berlin | Recruiting | Aug 19, 2022 |
All recruiting trials (5)
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Intensive GDMT optimization for women after heart failure hospitalization
This study tests whether rapidly increasing and closely monitoring heart failure meds in women after hospitalization can reduce death or readmission within a year.
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Ablation versus medication for atrial fibrillation in people with preserved or mildly reduced heart function
This trial will randomly assign adults with atrial fibrillation and heart failure with preserved or mildly reduced ejection fraction to either catheter ablation (rhythm control) or medications for rate control to see which approach leads to better survival, fewer hospital stays, and improved quality of life.
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Maridebart cafraglutide for people with obesity and preserved or mildly reduced ejection fraction heart failure
This trial will test whether adding maridebart cafraglutide to usual heart-failure care can reduce hospital visits, cardiovascular deaths, and improve symptoms in adults with obesity and HFpEF or HFmrEF.
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Using blood samples to identify heart failure risks in diabetes patients
This study is trying to see if blood tests can help find out which people with type 2 diabetes are at risk for heart failure.
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Catheter ablation for atrial fibrillation in heart failure patients
This study is testing if catheter ablation can help heart failure patients with atrial fibrillation avoid serious heart problems better than standard medication.
Related topics
Quick answers
How many Heart Failure With Mildly Reduced Ejection Fraction clinical trials are recruiting right now?
5, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 35 countries. The most sites are in France (2 trials), Germany (2 trials), Italy (2 trials), Canada (2 trials), Argentina (1 trial). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 4: 2, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.