Evaluating congestion markers in patients with acute heart failure and preserved ejection fraction

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The AHF-CODE preserved study is a prospective, non-randomized study focusing on patients hospitalized for acute heart failure with preserved ejection fraction. It aims to identify clinical, biological, and ultrasound markers of congestion at the time of hospital discharge that may predict the risk of death or rehospitalization within three months. The study involves various assessments, including Doppler ultrasounds and blood sample analyses, to gather comprehensive data on the patients' conditions. This information could help improve patient management and outcomes post-discharge.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients hospitalised for acute heart failure.
* Patient with preserved ejection fraction (FE ≥ 50%).
* Patients considered clinically discharging from hospitalisation for acute heart failure.
* Age ≥18 years
* Patients having received complete information regarding the study design and having signed their informed consent form.
* Patient affiliated to or beneficiary of a social security scheme.

Exclusion Criteria:

* Comorbidity for which the life expectancy is ≤ 3 months
* Dialysis patient (peritoneal dialysis or hemodialysis) or patients with glomerular filtration rate \<15 ml/min/m² at inclusion.
* History of lobectomy or pneumonectomy lung surgery
* Severe pulmonary or pleural pathology preventing reliable acquisition of lung ultrasound images: severe emphysema, chronic pleurisy, pulmonary fibrosis, etc.
* Pregnant woman, parturient or nursing mother
* Adult person subject to a legal protection measure (guardianship, curatorship, safeguard of justice)
* Adult person who is unable to give consent
* Person deprived of liberty by a judicial or administrative decision,
* Person subject to psychiatric care pursuant to Articles L. 3212-1 and L. 3213-1 of the Public Health Code.

Where it's running

• CHRU de Nancy
  Vandœuvre-lès-Nancy, France Recruiting

Study contacts

• Study coordinator: Nicolas GIRERD, MD,PhD
• Email: n.girerd@chru-nancy.fr
• Phone: + 33 3 83 15 73 22

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Infusion of furosemide to see if a loading infusion helps remove fluid better in acute heart failure

  This study tests whether giving furosemide as a continuous infusion with a loading dose is better at removing excess fluid than giving it as bolus injections in adults with acute heart failure.

  Recruiting Phase 4 University of Aarhus · Randers · NCT07577596

• Characterizing phenotypes of acute heart failure

  This project will try to see if heart function measures, imaging features (radiomics), and blood biomarkers can predict outcomes for adults hospitalized with acute heart failure, including cardiogenic shock.

  Recruiting Universitätsklinikum Hamburg-Eppendorf · Hamburg · NCT07508891

• Early finerenone treatment for hospitalized adults with acute heart failure and LVEF ≥40%

  This trial will test whether starting finerenone early during hospitalization helps adults with acute heart failure who have a left ventricular ejection fraction of 40% or higher.

  Recruiting at 13 sites Phase 4 Juntendo University · Handa, Aichi-ken and 20 other locations · NCT07397650

• Intensive GDMT optimization for women after heart failure hospitalization

  This study tests whether rapidly increasing and closely monitoring heart failure meds in women after hospitalization can reduce death or readmission within a year.

  Recruiting Phase 4 IRCCS Policlinico S. Donato · San Donato Milanese, MILANO and 11 other locations · NCT07295522

• Using intra‑abdominal pressure and bedside ultrasound to guide decongestive treatment in heart failure

  This trial will test whether using bladder pressure (intra‑abdominal pressure) measurements together with bedside ultrasound to guide IV loop diuretics helps people hospitalized with acute heart failure get rid of excess fluid more effectively than usual care.

  Recruiting Phase 3 Instituto de Investigación Sanitaria Aragón · Zaragoza and 1 other locations · NCT07008365

• Investigating heart issues in COPD patients during hospital stays

  This study is trying to see if sudden worsening of COPD can cause heart problems in hospitalized patients and how it affects their recovery.

  Recruiting Sahlgrenska University Hospital · Gothenburg, Region Västra Götaland · NCT06597331

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.