Continuous versus intermittent IV furosemide for acute heart failure

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

DiurHF is a prospective, multicenter observational comparison of two common intravenous loop diuretic regimens—continuous infusion versus intermittent boluses of furosemide—in patients admitted with acute decompensated heart failure. Participating Italian hospitals enroll adults with clinical signs of congestion and BNP >100 pg/mL and follow them through hospitalization. The study tracks changes in renal function, clinical congestion signs, BNP levels, and short-term clinical outcomes. Exclusions include end-stage renal disease, very high creatinine, recent myocardial infarction, severe hypotension, and major systemic illnesses.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients over 18 years;
* Patients with diagnosis of ADHF(dyspnea, orthopnea, peripheral edema or major fatigue and at least two clinical signs including rales, hepatomegaly, pulmonary congestion on chest radiography, jugular vein dilatation, or a third heart sound);
* Blood BNP \> 100 pg/mL;

ADHF: Acute Decompensated Heart Failure; BNP: B-type Natriuretic Peptide; IV: IntraVenous; LVEF: Left Ventricular Ejection Fraction.

Exclusion Criteria:

* Patients who receive more than 40 mg of IV furosemide;
* End-Stage renal disease or renal replacement therapy;
* Recent myocardial infarction (within thirty days of screening);
* Systolic blood pressure \< 80 mmHg;
* Creatinine levels \> 4 mg/dL;
* Patients affected by sepsis, liver diseases, inflammatory diseases or neoplastic diseases.

Where it's running

• Ospedale Madonna della Navicella
  Chioggia, Venezia, Italy Recruiting
• Azienda Ospedaliera di Padova
  Padova, Italy Recruiting
• University of Rome La Sapienza
  Roma, Italy Recruiting
• Department of Internal Medicine, Cardiovascular Diseases Unit
  Siena, Italy Recruiting

Study contacts

• Principal investigator: Alberto Palazzuoli, MD — University of Siena
• Study coordinator: Alberto Palazzuoli, MD
• Email: palazzuoli2@unisi.it
• Phone: +390577585363

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.