Condition

Congestive Heart Failure clinical trials and research

• 14Clinical trials
• 6NIH research projects
• 5Countries

Newest Congestive Heart Failure clinical trials

All recruiting trials (14)

• Community-informed approaches to equitable heart failure care in primary care

  This study tests whether engaging patients, caregivers, community health workers, and care teams can help Mayo Clinic develop equity-focused, practical care strategies for adults with congestive heart failure who face social challenges.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07730827

• Routine versus provisional distal perfusion catheter placement during mechanical circulatory support

  This study tests whether placing a distal perfusion catheter routinely or only provisionally improves limb outcomes in patients needing femoral artery support for mechanical circulatory support.

  Recruiting Samsung Medical Center · Changwon and 5 other locations · NCT07482865

• Peripheral Venous Pressure–Guided Care in Heart Failure

  In people with congestive heart failure, this study tests whether daily peripheral venous pressure measurements, used to guide treatment, can shorten hospital stays and reduce readmissions compared with standard care.

  Recruiting Wake Forest University Health Sciences · Milwaukee, Wisconsin · NCT07400042

• ADAPT palliative support for people living with heart failure

  This project will try weekly nurse- and social worker-led phone support (ADAPT) to see if it improves symptoms, mood, and quality of life for people living with heart failure in community clinics.

  Recruiting Indiana University · Indianapolis, Indiana · NCT07356843

• Using intra‑abdominal pressure and bedside ultrasound to guide decongestive treatment in heart failure

  This trial will test whether using bladder pressure (intra‑abdominal pressure) measurements together with bedside ultrasound to guide IV loop diuretics helps people hospitalized with acute heart failure get rid of excess fluid more effectively than usual care.

  Recruiting Phase 3 Instituto de Investigación Sanitaria Aragón · Zaragoza and 1 other locations · NCT07008365

• Pharmacy-led intervention to improve medication adherence after hospital discharge

  This study tests a pharmacy-led program to help low-income patients with multiple chronic conditions take their medications correctly after leaving the hospital.

  Recruiting University of Tennessee · Knoxville, Tennessee and 1 other locations · NCT06374277

• App to support post-hospital care for people with multiple chronic conditions

  This trial will test a smartphone/tablet app to help people aged 55+ with heart failure, diabetes, or chronic kidney disease manage their care after leaving the hospital.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT06051058

• Impact of wireless monitoring on heart failure patients

  This study tests if using wireless monitoring can help heart failure patients with pacemakers and defibrillators stay healthier and reduce unexpected hospital visits.

  Recruiting Saint Vincent's Hospital, Korea · Suwon, Kyonggi Do · NCT05971225

• Understanding TRPC6 to Prevent Heart Issues in Breast Cancer Patients Receiving Chemotherapy

  This study is trying to see if looking at a specific gene can help prevent heart problems in breast cancer patients who are getting chemotherapy.

  Recruiting at 2 sites Mayo Clinic · Gainesville, Florida and 1 other locations · NCT05507879

• Optimizing treatment for pulmonary edema and heart failure

  This study is testing which treatment works best for people with acute heart failure and pulmonary edema by comparing a diuretic, a vasodilator, and a combination of both.

  Recruiting at 4 sites Phase 4 Copenhagen University Hospital, Rigshospitalet · Copenhagen, Copenhagen and 4 other locations · NCT05276219

• Targeting SERCA2a to improve heart function in patients with heart failure

  This study is testing a new treatment that uses a virus to help improve heart function in people with heart failure by correcting how calcium is handled in heart cells.

  Recruiting at 5 sites Phase 1/2 Sardocor Corp. · San Diego, California and 4 other locations · NCT04703842

• Using PolyCore for fluid removal in heart failure patients

  This study is testing if a new treatment called PolyCore can help heart failure patients who still have symptoms feel better when added to their usual medications.

  Recruiting at 3 sites Phase 1/2 Iperboreal Pharma Srl · Chieti and 2 other locations · NCT03994874

• Examining heart tissue and blood in patients with severe heart disease

  This study collects heart tissue and blood samples from patients with severe heart disease to learn more about heart failure and compare them with samples from healthy individuals.

  Recruiting at 3 sites University of Utah · Murray, Utah and 2 other locations · NCT01099982

• Investigating blood proteins related to heart damage and failure

  This study is testing if two proteins in the blood can help tell the difference between people who have a heart attack and go on to develop heart failure and those who don’t.

  Recruiting UConn Health · Farmington, Connecticut · NCT00762333

NIH-funded research (6)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Transcatheter device to relieve heart failure by lowering left atrial pressure

  A new catheter-based device aims to help people with chronic heart failure by creating a small passage between the left and right atria to lower left atrial pressure and ease symptoms.

  NIH research Alleviant Medical, INC. · Austin, UNITED STATES · NIH-11289343

• A device to relieve pressure in the heart for treating congestive heart failure.

  This study is testing a new device that helps relieve symptoms of congestive heart failure by improving blood flow in the heart, and it's designed for patients with this condition who might benefit from a fresh treatment option.

  NIH research Alleviant Medical, INC. · Austin, UNITED STATES · NIH-11011326

• Using remote ischemic preconditioning to protect the kidneys and heart in heart failure patients

  This study is looking at a special technique that might help protect your kidneys and heart during certain medical procedures that use contrast dye, especially if you have heart failure or coronary artery disease. By briefly restricting blood flow to a limb, we hope to improve blood flow and reduce the risk of kidney d

  NIH research VA North Texas Health Care System · Dallas, United States · NIH-10980505

• Investigating the impact of stress on heart failure

  This study is looking at how stress impacts people with heart failure, aiming to find out what triggers stress that can make their symptoms worse, so we can help them manage their condition better and avoid hospital visits.

  NIH research Yale University · New Haven, United States · NIH-10892076

• Investigating how renal nerves affect heart failure treatment with SGLT2 inhibitors

  This study is looking at how a type of diabetes medication called SGLT2 inhibitors can help people with congestive heart failure by reducing fluid buildup in the body, and it aims to find out how the nerves in the kidneys play a role in this process.

  NIH research University of Nebraska Medical Center · Omaha, United States · NIH-10881799

• Improving care for African Americans with heart failure

  This study is looking for ways to improve heart failure care specifically for African Americans by finding better ways to understand their unique needs and working with healthcare providers to make sure they get the best treatment possible.

  NIH research Univ of Arkansas for Med Scis · Little Rock, United States · NIH-10790931

Related topics

Quick answers

How many Congestive Heart Failure clinical trials are recruiting right now?

14, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 5 countries. The most sites are in United States (9 trials), South Korea (2 trials), Spain (1 trial), Italy (1 trial), Denmark (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1/2: 2, Phase 3: 1, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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