Condition

Heart Failure With Preserved Ejection Fraction (HFPEF) clinical trials and research

• 28Clinical trials
• 2New in 30 days
• 40Countries

Newest Heart Failure With Preserved Ejection Fraction (HFPEF) clinical trials

All recruiting trials (28)

• Renal Nerve Stimulation to Help Blood Pressure in AF and HFpEF

  This study tests whether stimulating the kidneys with a catheter can safely lower blood pressure in adults with atrial fibrillation and HFpEF who also have hypertension.

  Recruiting London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · London, Ontario · NCT07893821

• Cardio-Metabolic Clinic care for adults with type 2 diabetes and cardiovascular disease

  This trial tests whether a specialized Cardio-Metabolic Clinic can improve heart function and overall health for adults with type 2 diabetes and cardiovascular disease compared with usual care.

  Recruiting Odense University Hospital · Svendborg · NCT07878325

• Optimised Cardio-Renal Care for CKD and heart disease

  This study tests whether a specialised Cardio-Renal Clinic can improve heart and kidney health and quality of life for adults with chronic kidney disease and cardiovascular disease.

  Recruiting Odense University Hospital · Svendborg · NCT07835828

• Resmetirom for MASH with HFpEF in adults

  This study tests whether resmetirom can be given safely and show liver-related effects in adults with MASH and heart failure with preserved ejection fraction over 24 weeks.

  Recruiting at 5 sites Phase 1 Madrigal Pharmaceuticals, Inc. · Peoria, Arizona and 4 other locations · NCT07830758

• Elecoglipron vs placebo for adults with HFpEF or HFmrEF

  This Phase 3 study tests whether elecoglipron helps people with HFpEF or HFmrEF who are on dapagliflozin and standard care.

  Recruiting at 24 sites Phase 3 AstraZeneca · Fairhope, Alabama and 678 other locations · NCT07761117

• Iron infusion and MRI to study inflammation in HFpEF

  A small early-phase study tests whether an iron infusion affects heart inflammation in people with HFpEF, using MRI measures before and after treatment.

  Recruiting Early Phase 1 University of Florida · Gainesville, Florida · NCT07634640

• Coronary stents for people with HFpEF and blocked heart arteries

  This trial will see if placing coronary artery stents (versus a placebo procedure) helps people with HFpEF and coronary artery disease feel better over six months.

  Recruiting Phase 2 King's College London · London · NCT07560436

• Heart failure with preserved ejection fraction in people with COPD: clinical course and prognosis

  This project will see how often HFpEF appears in people aged 50–70 hospitalized with COPD and whether having HFpEF changes their symptoms, exercise capacity, and prognosis.

  Recruiting at 2 sites National Medical Research Center for Therapy and Preventive Medicine · Kazan' and 1 other locations · NCT07375433

• Progressive Resistance Training First to Help AF and HFpEF Patients Feel Better

  This trial tests whether starting with progressive resistance training before aerobic exercise can improve exercise capacity and quality of life in people aged 60 and older who have atrial fibrillation and HFpEF.

  Recruiting Northwestern University · Chicago, Illinois · NCT07324772

• Intensive GDMT optimization for women after heart failure hospitalization

  This study tests whether rapidly increasing and closely monitoring heart failure meds in women after hospitalization can reduce death or readmission within a year.

  Recruiting Phase 4 IRCCS Policlinico S. Donato · San Donato Milanese, MILANO and 11 other locations · NCT07295522

• Ablation versus medication for atrial fibrillation in people with preserved or mildly reduced heart function

  This trial will randomly assign adults with atrial fibrillation and heart failure with preserved or mildly reduced ejection fraction to either catheter ablation (rhythm control) or medications for rate control to see which approach leads to better survival, fewer hospital stays, and improved quality of life.

  Recruiting at 4 sites Nova Scotia Health Authority · Halifax, Nova Scotia and 3 other locations · NCT07272902

• Finding hidden early heart failure in at-risk adults in major German cities using mobile MRI

  This project will test whether a mobile, telemedicine‑supervised screening using cardiac MRI, lab tests, and questionnaires can find hidden (asymptomatic) heart failure in adults aged 40–69 with heart risk factors living in large German cities.

  Recruiting German Heart Institute · Berlin · NCT07185100

• AI analysis of ECGs to detect structural heart disease

  This project will test whether AI can read traditional and wearable ECGs to find undiagnosed valve disease, pulmonary hypertension, and heart failure in adults.

  Recruiting at 6 sites Imperial College London · Bristol and 5 other locations · NCT07057466

• How kidneys handle protein and salt in people with HFpEF and obesity

  This study will test how kidneys process protein and salt after a high-protein, high-sodium meal in adults with obesity and heart failure with preserved ejection fraction compared with healthy and obese-only adults.

  Recruiting University of Mississippi Medical Center · Jackson, Mississippi · NCT07052539

• PDGFRβ PET imaging to detect cardiac fibrosis after heart attack or in HFpEF

  This project will test whether a PET tracer that binds PDGFRβ can spot fibrogenic cells in the hearts of people after a STEMI, in patients with HFpEF, and in healthy volunteers.

  Recruiting Uppsala University · Uppsala · NCT06956560

• AI-driven wearable monitoring for chronic heart failure

  This project will try an AI-driven wearable and mini‑invasive device to see if continuous home monitoring reduces hospital visits and improves health for adults with chronic heart failure.

  Recruiting University of Salerno · Salerno · NCT06909682

• Using advanced heart imaging to find HFpEF

  This project will test if advanced heart imaging and related tests can help diagnose people with breathlessness who have normal heart pumping but suspected HFpEF.

  Recruiting Sheffield Teaching Hospitals NHS Foundation Trust · Sheffield, South Yorkshire and 1 other locations · NCT06905405

• Eccentric exercise program for older adults with heart failure and muscle loss

  This study is testing a 12-week exercise program for older adults with heart failure and muscle loss to see if it can help them get stronger and feel better.

  Recruiting at 2 sites Universita di Verona · Verona, Verona and 1 other locations · NCT06826963

• Evaluating pregnancy factors and biomarkers in heart failure prognosis

  This study is trying to see how pregnancy-related factors and certain blood markers affect the heart health of women aged 60-74 who have heart failure with preserved ejection fraction.

  Recruiting National Medical Research Center for Therapy and Preventive Medicine · Moscow · NCT06803849

• Investigating the impact of heart fat on heart function in patients with heart failure

  This study is trying to see how fat around the heart affects heart function in people with heart failure, including those who are obese and those who are not.

  Recruiting University of Leicester · Leicester, Leicestershire · NCT06768437

• Identifying heart failure with preserved ejection fraction in Denmark

  This study is trying to find and screen older adults in Denmark who are at risk for heart failure with preserved ejection fraction to better understand how to identify this condition and help those who might be affected.

  Recruiting Herlev and Gentofte Hospital · Hellerup · NCT06685237

• Personalized dual‑chamber pacing for people with HFpEF

  This study will test whether programming a dual‑chamber pacemaker to a personalized heart rate helps people with symptomatic HFpEF (LVEF ≥50%) feel and function better.

  Recruiting at 53 sites Medtronic Cardiac Rhythm and Heart Failure · Phoenix, Arizona and 54 other locations · NCT06678841

• Assessing STM-01 for heart failure with preserved ejection fraction

  This study is testing a new drug called STM-01 to see if it is safe for people with heart failure that has preserved ejection fraction.

  Recruiting Phase 1 Secretome Therapeutics · Chicago, Illinois and 1 other locations · NCT06560762

• Understanding heart failure with preserved ejection fraction

  This study aims to learn more about heart failure with preserved ejection fraction to find better ways to diagnose and treat people who experience symptoms like breathlessness and fatigue.

  Recruiting at 26 sites Manchester University NHS Foundation Trust · Abercynon and 25 other locations · NCT05441839

• Understanding Heart Failure With Preserved Ejection Fraction

  This study looks at people with heart failure that has preserved ejection fraction to understand what causes it and find better tests and treatments.

  Recruiting Manchester University NHS Foundation Trust · Manchester · NCT05383287

• Assessing exercise capacity in heart failure patients with microvascular dysfunction and body composition analysis

  This study is testing how heart function, body makeup, and exercise ability are connected in people with heart failure who have chest pain but no blocked arteries.

  Recruiting Korea University Anam Hospital · Seoul · NCT04822649

• Right greater splanchnic nerve ablation to reduce HFpEF symptoms

  This test uses a catheter procedure (Satera Ablation System) that ablates the right greater splanchnic nerve to see if it improves symptoms in people with HFpEF.

  Recruiting at 17 sites Axon Therapies, Inc. · Birmingham, Alabama and 25 other locations · NCT04592445

• Examining small vessel disease in women with heart issues

  This study is trying to see how small blood vessel problems in the heart affect women with heart issues who don't have blocked arteries, to help understand heart failure better.

  Recruiting at 2 sites Cedars-Sinai Medical Center · Los Angeles, California and 1 other locations · NCT03876223

Related topics

Quick answers

How many Heart Failure With Preserved Ejection Fraction (HFPEF) clinical trials are recruiting right now?

28, as of November 12, 2026. 2 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 40 countries. The most sites are in United States (9 trials), United Kingdom (8 trials), Canada (4 trials), Italy (4 trials), Denmark (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 2, Phase 2: 1, Phase 3: 1, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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