Using MRI to measure lung fluid in patients with acute heart failure
MRI Assessment of Pulmonary Edema in Acute Heart Failure
This study is testing if using MRI can help measure lung fluid in people with acute heart failure to see if it can improve treatment and predict their chances of coming back to the hospital or facing serious issues later on.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 300 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Alberta Academic / other |
| Locations | 2 sites (Edmonton, Alberta and 1 other locations) |
| Trial ID | NCT03999138 on ClinicalTrials.gov |
What this trial studies
This study aims to improve the accuracy of measuring pulmonary edema, or fluid in the lungs, in patients with acute heart failure (AHF) using MRI technology. Researchers will assess lung water levels at the time of hospital admission and discharge to track changes during treatment. Additionally, the study will evaluate whether these measurements can predict the risk of hospital readmission or mortality related to heart failure. A total of 300 patients will be recruited from multiple centers, and their medical records will be followed for up to five years post-hospitalization.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older who are being treated for acute heart failure and are within 48 hours of starting diuretic therapy.
Not a fit: Patients who are critically ill or have contraindications to MRI will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to better management of acute heart failure by providing more accurate assessments of lung fluid levels, potentially improving patient outcomes.
How similar studies have performed: While the use of MRI in this context is relatively novel, similar studies have shown promise in improving diagnostic accuracy for heart failure-related conditions.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * 18 years of age or older and willing/able to provide informed consent * patients being treated for acute heart failure (including those patients with both reduced and preserved ejection fraction) * patients receiving medical therapy for pulmonary edema by current standard of care (including oral or IV diuretics) * patients identified within 48 hours of initiation of medical therapy for pulmonary edema, defined as the time of first diuretic (IV or PO) or escalation of existing diuretic therapy administered within the ED or hospital Exclusion Criteria: * contraindication to MRI * patient too critically ill/unstable as per the clinical care team for transport to MRI scanner within the required scanning window * moderate to severe dementia
Where this trial is running
Edmonton, Alberta and 1 other locations
- University of Alberta — Edmonton, Alberta, Canada (Active_not_recruiting)
- University of Ottawa Heart Institute — Ottawa, Ontario, Canada (Recruiting)
Study contacts
- Study coordinator: Ian Paterson, MD
- Email: DPaterson@ottawaheart.ca
- Phone: 613-696-7267
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.