Using MRI to measure lung fluid in patients with acute heart failure

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to improve the accuracy of measuring pulmonary edema, or fluid in the lungs, in patients with acute heart failure (AHF) using MRI technology. Researchers will assess lung water levels at the time of hospital admission and discharge to track changes during treatment. Additionally, the study will evaluate whether these measurements can predict the risk of hospital readmission or mortality related to heart failure. A total of 300 patients will be recruited from multiple centers, and their medical records will be followed for up to five years post-hospitalization.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 18 years of age or older and willing/able to provide informed consent
* patients being treated for acute heart failure (including those patients with both reduced and preserved ejection fraction)
* patients receiving medical therapy for pulmonary edema by current standard of care (including oral or IV diuretics)
* patients identified within 48 hours of initiation of medical therapy for pulmonary edema, defined as the time of first diuretic (IV or PO) or escalation of existing diuretic therapy administered within the ED or hospital

Exclusion Criteria:

* contraindication to MRI
* patient too critically ill/unstable as per the clinical care team for transport to MRI scanner within the required scanning window
* moderate to severe dementia

Where it's running

• University of Ottawa Heart Institute
  Ottawa, Ontario, Canada Recruiting
• University of Alberta
  Edmonton, Alberta, Canada Active not recruiting

Study contacts

• Study coordinator: Ian Paterson, MD
• Email: DPaterson@ottawaheart.ca
• Phone: 613-696-7267

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.