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Clinical trials and research at Seattle Children's Hospital

• 34Clinical trials
• 324NIH research projects
• 10Countries

Newest trials

All recruiting trials (34)

• Familial IBD Early Risk

  This study tests whether clinical, environmental, and immune factors in first-degree relatives of people with Crohn’s disease or ulcerative colitis can predict who will develop IBD.

  Recruiting Seattle Children's Hospital · Seattle, Washington · NCT07791862

• Long-Term Follow-Up of Gene Therapy Patients Treated at Seattle Children's

  This long-term follow-up study tests the safety of Seattle Children's Therapeutics gene therapy products in people who have already received at least one infusion, for up to 15 years after their last treatment.

  Recruiting Seattle Children's Hospital · Seattle, Washington · NCT07424157

• New ways to detect lung infections in people with cystic fibrosis

  This study is testing new methods to find harmful lung bacteria in people with CF who can still produce sputum, especially those on modern CF therapies.

  Recruiting at 6 sites Seattle Children's Hospital · La Jolla, California and 8 other locations · NCT07312734

• Organizational skills training versus a mindfulness-based group program for teens with ADHD

  This project will test whether an eight-session organizational skills program or an eight-session mindfulness program helps teens (ages 13–17) with ADHD when delivered as telehealth groups.

  Recruiting Seattle Children's Hospital · Seattle, Washington and 1 other locations · NCT07281092

• I-DECIDE: follow-up options after a child’s bronchiolitis hospitalization

  This trial tests two ways hospitals can encourage doctors to prescribe on‑as‑needed (PRN) follow-up instead of routine automatic visits for children hospitalized with bronchiolitis to see if families attend fewer unnecessary clinic visits.

  Recruiting at 62 sites Seattle Children's Hospital · Birmingham, Alabama and 61 other locations · NCT07243652

• GPC3-targeted CAR T cells armored with IL-15 and IL-21 for pediatric non‑CNS solid tumors

  This treatment will try personalized CAR T cells that target GPC3 and are engineered to make IL‑15 and IL‑21 in children and young adults with relapsed or refractory non‑CNS solid tumors that express GPC3.

  Recruiting Phase 1 Seattle Children's Hospital · Seattle, Washington · NCT07148050

• Concussion recovery and support program for young adults

  This pilot randomized trial will test whether a six-session online therapy called CRISP helps 18–30-year-olds with concussion-related headaches feel and function better.

  Recruiting at 2 sites Seattle Children's Hospital · Seattle, Washington and 1 other locations · NCT07097792

• High-resistance inspiratory muscle training to improve heart, blood vessel, and kidney health in young people with type 2 diabetes

  This trial will test whether about 5 minutes a day of high-resistance inspiratory muscle strength training can lower blood pressure and improve vascular and kidney function in youth and young adults with type 2 diabetes.

  Recruiting Seattle Children's Hospital · Seattle, Washington and 1 other locations · NCT06936670

• Understanding pain triggers in young adults with chronic pain

  This study is trying to find out what everyday factors make pain worse for young adults aged 18-25 who have had chronic pain since childhood.

  Recruiting Seattle Children's Hospital · Seattle, Washington · NCT06932432

• Using Tirzepatide to treat obesity in young adults with Prader-Willi Syndrome and hypothalamic obesity

  This study is testing if a weight loss medication called Tirzepatide can help young adults with Prader-Willi Syndrome and hypothalamic obesity lose weight and improve their health.

  Recruiting at 3 sites Phase 4 Seattle Children's Hospital · Saint Paul, Minnesota and 2 other locations · NCT06901245

• Research to improve treatments for cystic fibrosis patients not on modulators

  This study is trying to find better treatments for people with cystic fibrosis who aren't using current medications by collecting health information and samples to help guide future research.

  Recruiting at 64 sites Seattle Children's Hospital · Birmingham, Alabama and 67 other locations · NCT06504589

• Reversing autoimmunity in lupus using cell therapy

  This study is testing a new cell therapy to see if it can help young people with lupus who haven't responded to other treatments.

  Recruiting Phase 1 Seattle Children's Hospital · Seattle, Washington · NCT06465147

• Internet program for managing pain in pancreatitis patients

  This study is testing an online program that helps people with pancreatitis manage their pain better and improve their quality of life.

  Recruiting Seattle Children's Hospital · Seattle, Washington · NCT06386224

• Research on gut inflammation in pediatric patients with inflammatory bowel diseases

  This study is trying to learn more about gut inflammation in kids with inflammatory bowel diseases by collecting health information and samples from them and comparing it to kids who have different gut issues but no inflammation.

  Recruiting Seattle Children's Hospital · Seattle, Washington · NCT06315179

• Comparing two types of nutrition for children with Crohn's disease

  This study is testing whether a regular nutrition formula or a homemade smoothie recipe works better for kids with Crohn's disease to see which one helps them feel better.

  Recruiting Seattle Children's Hospital · Philadelphia, Pennsylvania and 2 other locations · NCT06216899

• 'What Is Important to Us' communication program for families of children with severe neurological impairment in the ICU

  This intervention will try a photo‑narrative communication program with parents of children (6 months–25 years) who have severe neurological impairment in the pediatric ICU and their clinicians to see if it is feasible, acceptable, and helpful.

  Recruiting Phase 2 Seattle Children's Hospital · Seattle, Washington · NCT06208332

• Examining how different feeding methods affect gut health in newborns with gastrointestinal issues

  This study is testing whether feeding newborns with gastrointestinal issues an exclusive human milk diet helps improve their gut health and feeding progress compared to standard feeding methods.

  Recruiting Seattle Children's Hospital · Seattle, Washington · NCT06072976

• Program to improve health after concussion in youth

  This study is testing a new online program that helps teenagers aged 11-18 who have ongoing symptoms after a concussion feel better and improve their quality of life.

  Recruiting Seattle Children's Hospital · Dallas, Texas · NCT06036147

• Comparing two models of well-child care for Black families

  This study is trying out a new approach to well-child care for Black families in low-income areas to see if having community health workers as support helps them get better care and resources for their children.

  Recruiting Seattle Children's Hospital · Honolulu, Hawaii and 2 other locations · NCT05852392

• Mobile app to help teens and young adults with cancer manage stress

  This study tests a mobile app that helps teens and young adults with cancer manage stress and improve their mental health.

  Recruiting Seattle Children's Hospital · Seattle, Washington · NCT05842902

• Online program to help parents with IBS support their children

  This study is testing an online program to see if it can help parents with IBS support their young children and reduce their tummy pain.

  Recruiting Seattle Children's Hospital · Seattle, Washington · NCT05730491

• Improving family media use planning through shared decision making

  This study is testing a new program to help families with kids aged 11-17 improve their media use habits by making decisions together about screen time.

  Recruiting Seattle Children's Hospital · Seattle, Washington · NCT05722535

• Comparing antibiotic treatments for lung issues in cystic fibrosis

  This study is testing whether a combination of two types of antibiotics can help people with cystic fibrosis recover better from lung problems than using just one type of antibiotic.

  Recruiting at 59 sites Phase 4 Seattle Children's Hospital · Birmingham, Alabama and 59 other locations · NCT05548283

• Bilingual education and navigation program for Hispanic children with brain injuries

  This study is testing a bilingual education and support program to help Hispanic families with children who have brain injuries access and stick with rehabilitation services for better recovery.

  Recruiting at 4 sites Seattle Children's Hospital · Colorado Springs, Colorado and 5 other locations · NCT05261477

• Using modified T cells to treat young patients with relapsed or refractory leukemia

  This study is testing a new treatment using modified T cells to see if it can help young patients with tough-to-treat leukemia feel better.

  Recruiting Phase 1 Seattle Children's Hospital · Seattle, Washington · NCT05105152

• Improving suicide prevention strategies for teens

  This study is testing two new ways to help teens aged 11-17 who are at risk of suicide to see if they work better than regular care.

  Recruiting at 2 sites Seattle Children's Hospital · Columbus, Ohio and 1 other locations · NCT05078970

• Effects of Metformin and Automated Insulin Delivery on Youth with Type 1 Diabetes

  This study is testing if adding metformin and an automated insulin delivery system can help young people with type 1 diabetes improve their kidney and heart health.

  Recruiting Phase 1 Seattle Children's Hospital · Aurora, Colorado and 1 other locations · NCT05065372

• Laser treatment for twin-to-twin transfusion syndrome

  This study is testing if a laser treatment can improve outcomes for pregnant women with twin-to-twin transfusion syndrome by targeting the blood vessels connecting their twins.

  Recruiting Seattle Children's Hospital · Seattle, Washington and 1 other locations · NCT05008744

• Understanding how puberty affects kidney health in youth with diabetes

  This study looks at how puberty affects kidney health in teenagers with type 2 diabetes and obesity to see if the changes during this time can harm their kidneys.

  Recruiting at 2 sites Seattle Children's Hospital · Aurora, Colorado and 1 other locations · NCT05008276

• Registry for chronic nonbacterial osteomyelitis

  This study is creating a registry to track how children and teens with chronic nonbacterial osteomyelitis respond to different treatments over time to help improve their care.

  Recruiting Seattle Children's Hospital · Seattle, Washington · NCT04725422

• Evaluating the effects of CFTR modulators in young children with cystic fibrosis

  This study is testing how CFTR modulators affect growth and health in young children with cystic fibrosis over five years.

  Recruiting at 35 sites Seattle Children's Hospital · Birmingham, Alabama and 34 other locations · NCT04509050

• IV Gallium treatment for cystic fibrosis patients with NTM infections

  This study is testing if IV gallium can safely help adults with cystic fibrosis who have NTM infections feel better.

  Recruiting at 10 sites Phase 1 Seattle Children's Hospital · Birmingham, Alabama and 9 other locations · NCT04294043

• Locoregional immunotherapy using CAR T cells for pediatric brain tumors

  This study is testing a new treatment using specially modified immune cells to see if it can help children and young adults with certain types of brain tumors feel better.

  Recruiting Phase 1 Seattle Children's Hospital · Seattle, Washington · NCT04185038

• Hydrocortisone treatment for children with septic shock

  This study is testing if hydrocortisone can help children with severe septic shock recover better and avoid further health problems.

  Recruiting at 34 sites Phase 3 Seattle Children's Hospital · Tucson, Arizona and 43 other locations · NCT03401398

NIH-funded research (newest 40 of 324)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Enhanced surveillance to understand vaccine-preventable infections in kids

  This project actively follows children in Seattle to measure how common vaccine-preventable tummy and chest infections are and how well vaccines like flu and rotavirus work.

  NIH research Seattle Children's Hospital · Seattle, United States · NIH-11624223

• UMPIRE Protocol: Preserving Kidney Function in Young Children with Spina Bifida

  A pediatric kidney-preservation study aims to improve long-term kidney function in young children with spina bifida.

  NIH research Seattle Children's Hospital · Seattle, United States · NIH-11616590

• Bioengineered human brain vessels to study cerebral malaria and explore new therapies

  Researchers are testing a new 3D model of human brain blood vessels to understand how cerebral malaria causes damage and to identify possible adjunctive treatments for children.

  NIH research Seattle Children's Hospital · Seattle, United States · NIH-11563774

• Inflammation-linked autophagy problems in blood cells with sickle cell disease

  A scientist is studying how inflammation from TNF-alpha affects autophagy in platelets and red blood cells of people with sickle cell disease to better understand why blood clotting and cell health go awry.

  NIH research Seattle Children's Hospital · Seattle, United States · NIH-11539153

• Malaria vaccine and infection: how the body’s early and later immune responses relate to protection

  Researchers are studying how people’s immune systems respond to the malaria pre-erythrocytic stage, whether after vaccination or infection, to identify which responses are linked to protection.

  NIH research Seattle Children's Hospital · Seattle, United States · NIH-11535221

• Using a simple breathing test to check lung function after kids’ acute respiratory failure

  A study will test a child-friendly breathing method (oscillometry) to check how well lungs work after severe respiratory illness in kids.

  NIH research Seattle Children's Hospital · Seattle, United States · NIH-11530755

• Why vivax malaria hides in the liver and causes relapses

  Researchers are using single-cell sequencing and human liver–chimeric mice to learn how Plasmodium vivax parasites go dormant in the liver and later cause relapses in people exposed to vivax malaria.

  NIH research Seattle Children's Hospital · Seattle, United States · NIH-11503955

• MN1 gene role in brain malformations and developmental disorders

  Researchers will study how MN1 mutations affect brain development to understand conditions like PMG, RES, autism, and related IDD.

  NIH research Seattle Children's Hospital · Seattle, United States · NIH-11499083

• Chronic nonbacterial bone disease in kids: analyzing real-world data across many clinics

  This grant uses patient data from many centers to understand how well current treatments work for chronic nonbacterial osteomyelitis in children and young adults.

  NIH research Seattle Children's Hospital · Seattle, United States · NIH-11494236

• How breastmilk T cells may protect infants' airways

  This project looks at whether immune T cells in breast milk help protect breastfed infants from respiratory infections by moving between the mother's nose and breast.

  NIH research Seattle Children's Hospital · Seattle, United States · NIH-11482691

• Bifidobacterium infantis in infancy to boost immunity for babies exposed to HIV

  A small trial will test whether giving a probiotic B. infantis to breastfed infants exposed to HIV but uninfected can help boost their developing immune system.

  NIH research Seattle Children's Hospital · Seattle, United States · NIH-11474044

• Engineered CAR T immune cells targeting GPC3 for children's solid tumors

  Engineered CAR T immune cells that produce IL-15 and IL-21 to better find and fight GPC3-positive solid tumors in children.

  NIH research Seattle Children's Hospital · Seattle, United States · NIH-11468394

• How prenatal phthalate exposure may affect the placenta and birth timing

  This research looks at how chemicals called phthalates during pregnancy could change the placenta and influence whether a baby is born early or on time.

  NIH research Seattle Children's Hospital · Seattle, United States · NIH-11465137

• Understanding Craniofacial Microsomia: Visual Tools for Caregiver Education and Clinician Communication

  A project to create visual, easy-to-understand diagrams to help families and clinicians talk about craniofacial microsomia in children aged 0-11.

  NIH research Seattle Children's Hospital · Seattle, United States · NIH-11463053

• Motivational Interviewing–Enhanced CBT for Adults with ADHD

  A new program tests whether adding Motivational Interviewing to CBT helps adults with ADHD engage in treatment and improve daily functioning.

  NIH research Seattle Children's Hospital · Seattle, United States · NIH-11457017

• Prime-pull TB vaccine to boost lung-resident T cells

  A new TB vaccine approach aims to better protect children by boosting lung-trapped immune cells that fight TB.

  NIH research Seattle Children's Hospital · Seattle, United States · NIH-11451312

• PROSPER: Recovery and outcomes after severe pediatric respiratory illness

  This grant seeks to understand how kids recover their lung function and daily lives after serious respiratory illnesses like pneumonia or bronchiolitis, so doctors can help families plan and improve long-term health.

  NIH research Seattle Children's Hospital · Seattle, United States · NIH-11449268

• Mechanistic clues about lupus from immune disorders

  This grant looks at why certain immune disorders in people with genetic immune problems lead to lupus-like symptoms, by studying patients and mouse models.

  NIH research Seattle Children's Hospital · Seattle, United States · NIH-11449228

• Safer T cell engagers for pediatric and adult brain tumors

  A potential new treatment using T cell engaging proteins to help fight brain tumors in both children and adults.

  NIH research Seattle Children's Hospital · Seattle, United States · NIH-11448639

• Pubertal Kidney Injury in Diabetes: Kidneys, Markers, and Paths to Young Adulthood

  A study following teens with diabetes to see how puberty affects kidney health and what markers predict early kidney problems.

  NIH research Seattle Children's Hospital · Seattle, United States · NIH-11448514

• Transgenesis in a new mammalian model to study adult regeneration

  A medical research project aims to create genetically modified Acomys mice to understand how adult tissues can regenerate and how this could lead to new ways to treat fibrotic diseases.

  NIH research Seattle Children's Hospital · Seattle, United States · NIH-11445675

• Role of eosinophils in immune-related adverse events from CAR-T therapy

  This grant explores how eosinophils contribute to serious side effects like IEC-HS and ICANS in patients receiving CAR-T cancer therapy, with the goal of preventing these toxic events.

  NIH research Seattle Children's Hospital · Seattle, United States · NIH-11432529

• Engineered B cells designed to deliver therapy directly in the gut

  These researchers are testing a way to reprogram gut-homing B cells to deliver therapy right where inflammatory bowel disease occurs.

  NIH research Seattle Children's Hospital · Seattle, United States · NIH-11430087

• Targeting FLVCR1-enabled choline use in a aggressive AML subtype

  A new approach aims to block how a specific leukemia subtype (CG-AML) takes up choline to feed its growth, potentially slowing or stopping the disease.

  NIH research Seattle Children's Hospital · Seattle, United States · NIH-11427960

• Protecting adults with intellectual and developmental disabilities from sexual violence through Special Olympics education

  A program is testing a Special Olympics curriculum that teaches healthy relationships, consent, and safety to adults with IDD to reduce risk of sexual violence.

  NIH research Seattle Children's Hospital · Seattle, United States · NIH-11421114

• Copper vs Levonorgestrel IUDs and vaginal health in young African women at risk for HIV

  A randomized study will compare copper and levonorgestrel IUDs to see how they affect vaginal microbiota and mucosal barriers in young African women living with HIV or at risk for HIV.

  NIH research Seattle Children's Hospital · Seattle, United States · NIH-11420467

• Using a national pediatric health system to map chronic primary pain in kids and guide faster, kid-friendly care

  A big data project uses electronic records and patient data from children to identify which kids have chronic primary pain and how to give them timely, personalized care.

  NIH research Seattle Children's Hospital · Seattle, United States · NIH-11419915

• Diabetes in Youth and Young Adults in the Pacific Northwest

  A regional effort to learn how type 1 and type 2 diabetes develops and is managed in young people and young adults, especially in underserved communities.

  NIH research Seattle Children's Hospital · Seattle, United States · NIH-11417758

• How inherited maternal cells might shape babies’ BCG immune responses

  In babies born to mothers with HIV exposure, this study looks at whether maternal cells passed before birth affect how well the BCG vaccine sparks immune responses.

  NIH research Seattle Children's Hospital · Seattle, United States · NIH-11413444

• Bispecific antibodies to help kids fight neuroblastoma and brain tumors

  A pediatric-focused grant tests new bispecific antibodies that help the immune system attack childhood cancers like neuroblastoma and brain tumors.

  NIH research Seattle Children's Hospital · Seattle, United States · NIH-11413442

• Shared decision-making tool to improve firearm storage in families with children

  A patient-friendly trial tests a web-based tool that helps families decide together how to store firearms safely when children are in the home.

  NIH research Seattle Children's Hospital · Seattle, United States · NIH-11408777

• Protecting kidney health in young children with spina bifida

  This project tries specific urologic care plans to protect kidney function in young children who have spina bifida.

  NIH research Seattle Children's Hospital · Seattle, United States · NIH-11403051

• Endothelial-Leukocyte Adhesion in CAR T Cell Neurotoxicity

  Aims to understand why some kids treated with CAR T cells for leukemia or lymphoma develop brain-related side effects, by studying how white blood cells interact with brain blood vessels in a mouse model.

  NIH research Seattle Children's Hospital · Seattle, United States · NIH-11399986

• Circadian rhythms in pediatric asthma: how night-time immune responses shape disease

  A doctor-led study at Seattle Children’s Hospital will study how the body's internal clock affects airway immune responses in children with asthma, especially during nighttime viral infections.

  NIH research Seattle Children's Hospital · Seattle, United States · NIH-11399914

• biomarker-guided liposome therapy in pediatric cancer

  A doctor is researching how a specific biomarker, SLC46A3, influences how well liposome-based cancer drugs work, with a focus on pediatric neuroblastoma.

  NIH research Seattle Children's Hospital · Seattle, United States · NIH-11398877

• Internet-delivered pain self-management for pancreatitis

  A digital cognitive-behavioral therapy program helps people with recurrent acute or chronic pancreatitis reduce pain and how much it interferes with daily life.

  NIH research Seattle Children's Hospital · Seattle, United States · NIH-11398838

• LEAP: Improving Cleft Care for Children Worldwide

  A global, collaborative effort to speed up and improve the care children born with cleft lip and palate receive, with a focus on the first 10 years of life.

  NIH research Seattle Children's Hospital · Seattle, United States · NIH-11394035

• Shared Reading Support for Kids with Cleft Lip/Palate

  A family-friendly program helps children with oral clefts improve language and literacy through guided reading, coordinated with regular craniofacial visits and remote coaching for families in all areas.

  NIH research Seattle Children's Hospital · Seattle, United States · NIH-11392729

• Kids CoLab: Helping kids with kidney disease take an active role in decisions about their care

  A project to help children with kidney disease learn to participate in decisions about their own care as they move from pediatric to adult health services.

  NIH research Seattle Children's Hospital · Seattle, United States · NIH-11391279

• MEND: How prenatal exposures shape a child's brain and behavior

  This study looks at how multiple prenatal environmental exposures together affect a child’s brain development and behavior, using DNA from cord blood and data from thousands of children.

  NIH research Seattle Children's Hospital · Seattle, United States · NIH-11391230

Quick answers

How many clinical trials run by Seattle Children's Hospital are recruiting right now?

34, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 10 countries. The most sites are in United States (34 trials), Canada (4 trials), Brazil (1 trial), Israel (1 trial), Japan (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 6, Phase 4: 2, Phase 2: 1, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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