Endothelial-Leukocyte Adhesion in CAR T Cell Neurotoxicity
Official title: Endothelial-Leukocyte Adhesion in CAR T Cell Treatment Associated Neurotoxicity
Funded at Seattle Children's Hospital · NIH-11399986 · Data updated 2026-11-12
Aims to understand why some kids treated with CAR T cells for leukemia or lymphoma develop brain-related side effects, by studying how white blood cells interact with brain blood vessels in a mouse model.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Seattle Children's Hospital NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | September 22, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $578,929 |
| NIH project number | 5R37CA275954-04 |
| Project ID | NIH-11399986 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not a patient-facing study; involves animal models and mechanistic biology related to pediatric CAR T therapy.
✕Less likely to help
No direct benefit to patients from participating in this specific animal study or mechanistic experiments.
What this research studies
This project uses a mouse model to study how immune cells and blood vessels interact after CAR T cell therapy to cause neurologic side effects. Researchers will observe capillary plugging and vessel remodeling in the brain using advanced imaging, and identify the molecules and cell types involved. The goal is to map the steps from systemic inflammation to brain dysfunction so clinicians can foresee and prevent neurotoxicity in pediatric patients.
Why it matters
Potential benefit: Understanding these mechanisms could lead to strategies that prevent or lessen neurologic side effects in children receiving CAR T cell therapy.
How similar studies have gone: Preclinical work in CAR T neurotoxicity has shown capillary involvement and inflammation can drive brain dysfunction, with some success in translating findings to potential interventions.
Where this research is happening
-
Seattle Children's Hospital
Seattle, United States Active
Researchers
- Principal investigator: Gust, Juliane — Seattle Children's Hospital
- Study coordinator: Gust, Juliane
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.