Understanding how puberty affects kidney health in youth with diabetes

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the relationship between puberty and kidney health in adolescents with type 2 diabetes and obesity. It aims to understand how the physiological changes during puberty may lead to kidney injury, particularly focusing on the concept of kidney hypoxia. The study will utilize functional magnetic resonance imaging (MRI) and other assessments over a five-year period to evaluate the impact of these changes on kidney function. By identifying the mechanisms linking puberty and diabetic kidney disease, the research seeks to inform strategies for preserving kidney health in affected youth.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* HbA1c ≥6.0% for untreated high-risk group
* BMI ≥ 85th %ile for high-risk group
* Normal HbA1c ≤5.6% for control group
* Type 1 diabetes (T1D) Antibody negative

Exclusion Criteria:

* History of Chronic kidney disease (CKD) or acute kidney injury (AKI)
* Metabolic disorder prohibiting safe fasting
* Iodine or penicillin allergy
* Pregnancy
* Thrombophilia
* MRI contraindications
* Hormone therapy

Where it's running

• Children's Hospital Colorado
  Aurora, Colorado, United States Recruiting
• Seattle Children's Hospital
  Seattle, Washington, United States Recruiting

Study contacts

• Principal investigator: Petter Bjornstad, MD — University of Washington - Medicine Diabetes Institute
• Study coordinator: Petter Bjornstad, MD
• Email: pettermb@uw.edu
• Phone: (206) 616 3543

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.