Laser treatment for twin-to-twin transfusion syndrome
Official title: Laser Photocoagulation of Communicating Vessels in Twin-to-Twin Transfusion Syndrome (TTTS)
Run by Seattle Children's Hospital · NCT05008744 · Data updated 2026-11-12
This study is testing if a laser treatment can improve outcomes for pregnant women with twin-to-twin transfusion syndrome by targeting the blood vessels connecting their twins.
Quick facts
| Study type | Observational |
|---|---|
| Sex | Women only |
| Enrollment | 2000 (estimated) |
| Sponsor | Seattle Children's Hospital Academic / other |
| Locations | 2 sites (Seattle, Washington and 1 other locations) |
| Status | Recruiting |
| Started | October 1, 2021 |
| Main results expected | October 1, 2031 |
| Study ends | October 1, 2031 |
| Registry record updated | April 19, 2024 |
| Trial ID | NCT05008744 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are pregnant women with monochorionic twins diagnosed with TTTS, characterized by polyhydramnios in one twin and oligohydramnios in the other.
✕Probably not a fit
Patients with major congenital anomalies, active pre-term labor, or other serious complications may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study evaluates the effectiveness of diode laser photocoagulation on communicating vessels in cases of twin-to-twin transfusion syndrome (TTTS). Patients will undergo a thorough evaluation, including ultrasound assessments to check for congenital anomalies and fetal health. The procedure involves fetoscopic laser ablation performed under anesthesia, guided by ultrasound to ensure precision. Data on maternal and fetal outcomes will be collected to assess the procedure's impact.
Why it matters
Potential benefit: If successful, this treatment could significantly improve outcomes for mothers and their twins affected by TTTS.
How similar studies have gone: Previous studies have shown promising results with fetoscopic laser ablation in TTTS, indicating a potential for success in this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Single placenta (Monochorionic) * Polyhydramnios present in recipient twin (Greater than 8 cm maximum vertical pocket below 20 weeks and greater than a 10 cm pocket for greater than 20 weeks gestational age) * Oligohydramnios present in donor twin (Less than 2 cm maximum vertical pocket) * Prominent bladder in the recipient/ non-filling bladder in the donor * Thin dividing membrane Exclusion Criteria: * Patients unwilling to participate in the study or to be followed up * Presence of major congenital anomalies incompatible with survival * Active pre-term labor Ruptured membranes * Chorioamnionitis * Vaginal bleeding
Where it's running
-
Seattle Childrens Hospital
Seattle, Washington, United States Recruiting -
University of Washington
Seattle, Washington, United States Active not recruiting
Study contacts
- Principal investigator: Martin P Walker, MD — Seattle Childrens Hospital
- Study coordinator: Martin P Walker, MD
- Email: martin.walker@seattlechildrens.org
- Phone: 206-987-3539
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.