Chronic nonbacterial bone disease in kids: analyzing real-world data across many clinics
Official title: Retrospective and Prospective Study in Chronic Nonbacterial Osteomyelitis of Clinic-based Multicenter Data Collection
Funded at Seattle Children's Hospital · NIH-11494236 · Data updated 2026-11-12
This grant uses patient data from many centers to understand how well current treatments work for chronic nonbacterial osteomyelitis in children and young adults.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Seattle Children's Hospital NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | September 1, 2026 |
| Project end | August 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $399,599 |
| NIH project number | 1R01FD008230-01A1 |
| Project ID | NIH-11494236 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children and young adults diagnosed with chronic nonbacterial osteomyelitis/CRMO who have received second-line therapies.
✕Less likely to help
Patients who respond well to NSAIDs alone or whose disease course is milder may see less direct benefit.
What this research studies
Researchers will look at existing data from CHOIR and a pediatric rheumatology survey to see how second-line therapies perform over five years from diagnosis. They will use validated outcome scores to measure disease activity and how treatments impact quality of life. The study leverages a large, multicenter registry to compare real-world effectiveness of NSAIDs, csDMARDs, TNF inhibitors, and bisphosphonates. The goal is to identify which treatments help patients achieve better disease control and function.
Why it matters
Potential benefit: Findings could guide doctors in choosing the most effective treatments for CNO, improving pain and quality of life for patients.
How similar studies have gone: The CHOIR registry has already collected data showing treatment patterns; this project aims to validate and extend those findings.
Where this research is happening
-
Seattle Children's Hospital
Seattle, United States Active
Researchers
- Principal investigator: Zhao, Yongdong — Seattle Children's Hospital
- Study coordinator: Zhao, Yongdong
Related research
Other NIH-funded projects on the same topics.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.