Enhanced surveillance to understand vaccine-preventable infections in kids
Official title: IP21-002, Enhanced Surveillance to Assess Vaccine Preventable Enteric and Respiratory Virus Illnesses
Funded at Seattle Children's Hospital · NIH-11624223 · Data updated 2026-11-12
This project actively follows children in Seattle to measure how common vaccine-preventable tummy and chest infections are and how well vaccines like flu and rotavirus work.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Seattle Children's Hospital NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | September 1, 2021 |
| Project end | August 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $598,000 |
| NIH project number | 6U01IP001157-05M002 |
| Project ID | NIH-11624223 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children and adolescents in the Seattle area who are seeking care at Seattle Children’s Hospital or affiliated clinics, plus healthy children who can participate as controls.
✕Less likely to help
Some participants may not experience direct clinical benefit, but their data will help improve understanding and prevention of illnesses in others.
What this research studies
Researchers will enroll children receiving care at Seattle Children’s Hospital and affiliated clinics to track stomach and respiratory illnesses and also include a group of healthy, asymptomatic kids for comparison. They will collect clinical information, vaccine histories, and specimens (respiratory swabs and stool) to understand the burden and transmission of virus-caused diseases such as flu, rotavirus, norovirus, RSV, and SARS-CoV-2. Data will be gathered from King County and Snohomish County residents, with flexible enrollment methods during COVID-19 including verbal consent or online processes as approved. The study leverages existing vaccination records to evaluate how current vaccines perform in real-world settings. Molecular tests will identify pathogens to map epidemiology and natural history across inpatient, ED, and community contexts.
Why it matters
Potential benefit: If successful, the findings could improve how we prevent and control common viral infections in children and inform vaccine policy and care practices.
How similar studies have gone: Similar active surveillance studies have successfully characterized burden and vaccine impact for pediatric infections, supporting relevance of this approach.
Where this research is happening
-
Seattle Children's Hospital
Seattle, United States Active
Researchers
- Principal investigator: Englund, Janet a — Seattle Children's Hospital
- Study coordinator: Englund, Janet a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.