Registry for chronic nonbacterial osteomyelitis
CHronic Nonbacterial Osteomyelitis International Registry (CHOIR)
Seattle Children's Hospital · NCT04725422
This study is creating a registry to track how children and teens with chronic nonbacterial osteomyelitis respond to different treatments over time to help improve their care.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 2000 (estimated) |
| Ages | N/A to 21 Years |
| Sex | All |
| Sponsor | Seattle Children's Hospital (other) |
| Locations | 1 site (Seattle, Washington) |
| Trial ID | NCT04725422 on ClinicalTrials.gov |
What this trial studies
This study aims to create a prospective registry for chronic recurrent multifocal osteomyelitis (CRMO) and chronic nonbacterial osteomyelitis (CNO) to better understand the disease's natural history and patient responses to various treatments over a decade. It focuses on children and adolescents affected by this autoinflammatory bone disease, which can lead to serious complications if not treated properly. The registry will collect data on clinical assessments, imaging studies, and treatment outcomes to standardize care and improve management strategies for affected patients.
Who should consider this trial
Good fit: Ideal candidates for this study are children and adolescents aged 21 years or younger who exhibit bone edema on MRI and meet specific diagnostic criteria.
Not a fit: Patients with a history of malignancy or current infectious osteomyelitis will not benefit from this study.
Why it matters
Potential benefit: If successful, this registry could lead to improved treatment protocols and outcomes for patients with chronic nonbacterial osteomyelitis.
How similar studies have performed: Other studies have shown success in establishing disease registries for similar conditions, indicating a potential for valuable insights and advancements in treatment.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * \- Age at enrollment is equal to or younger than 21 years of age * Presence of bone edema on STIR or T2 fat saturation sequence on MRI within 12 weeks of enrollment * Whole body imaging evaluation (either WB MRI or bone scintigraphy) * Bone biopsy to exclude infection or malignancy unless bone lesions follow typical distribution or there is IBD, psoriasis, or palmar plantar pustulosis Exclusion Criteria: * \- History of or current malignancy * Current infectious osteomyelitis * Contraindication to the selected treatment agent
Where this trial is running
Seattle, Washington
- Seattle Children's Hospital — Seattle, Washington, United States (RECRUITING)
Study contacts
- Study coordinator: Yongdong (Dan) Zhao, MD, PhD
- Email: crmoresearch@seattlechildrens.org
- Phone: 206-987-2000
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Chronic Nonbacterial Osteomyelitis, Chronic Recurrent Multifocal Osteomyelitis