PROSPER: Recovery and outcomes after severe pediatric respiratory illness
Official title: PROSPER: Pulmonary Recovery and Outcomes after Severe Pediatric Respiratory Illness
Funded at Seattle Children's Hospital · NIH-11449268 · Data updated 2026-11-12
This grant seeks to understand how kids recover their lung function and daily lives after serious respiratory illnesses like pneumonia or bronchiolitis, so doctors can help families plan and improve long-term health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Seattle Children's Hospital NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | September 1, 2026 |
| Project end | May 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $930,637 |
| NIH project number | 1R01HL183628-01A1 |
| Project ID | NIH-11449268 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children and adolescents who survived acute respiratory failure from illnesses such as pneumonia, bronchiolitis, or asthma, and who are within the pediatric age range studied (including younger children).
✕Less likely to help
Children who do not experience impaired pulmonary function or quality-of-life issues after acute respiratory illness may derive limited direct benefit.
What this research studies
The project follows children who survive acute respiratory failure to see how their lungs recover over time and how this affects their activity, school participation, and quality of life. It will track pulmonary function, physical activity, and well-being across multiple centers, using age-appropriate assessments that go beyond basic spirometry. By identifying factors linked to worse outcomes, the study aims to point to targets for interventions that could improve long-term health for pediatric patients. The research is designed to minimize participant burden while capturing long-term recovery trajectories in a real-world setting.
Why it matters
Potential benefit: If successful, the study could inform better post-hospital care and rehabilitation strategies to improve lung recovery and quality of life for children after serious respiratory illness.
How similar studies have gone: Previous smaller studies showed impaired lung function after pediatric critical illness, but they often lacked multi-timepoint data and broader life impact assessment; this study builds on that groundwork with longitudinal, multi-domain measurements.
Where this research is happening
-
Seattle Children's Hospital
Seattle, United States Active
Researchers
- Principal investigator: Killien, Elizabeth Y — Seattle Children's Hospital
- Study coordinator: Killien, Elizabeth Y
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.