Pubertal Kidney Injury in Diabetes: Kidneys, Markers, and Paths to Young Adulthood
Official title: Pubertal Kidney Injury in Diabetes: Phenotypes, Biomarkers, Trajectories
Funded at Seattle Children's Hospital · NIH-11448514 · Data updated 2026-11-12
A study following teens with diabetes to see how puberty affects kidney health and what markers predict early kidney problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Seattle Children's Hospital NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | August 27, 2021 |
| Project end | June 30, 2031 |
| Funding year | 2026 |
| Award (this year) | $806,676 |
| NIH project number | 2R01DK129211-06 |
| Project ID | NIH-11448514 on NIH RePORTER |
Who could benefit from this research
✓Could help
Young people with type 1 or type 2 diabetes, transitioning through puberty, who are at risk for or showing early signs of kidney stress.
✕Less likely to help
Teens without diabetes or those not undergoing puberty may not directly benefit from this study.
What this research studies
This project follows youths with type 1 or type 2 diabetes through puberty to understand how hormonal and metabolic changes impact the kidneys. It builds on a prior study that used advanced tests like measured GFR, renal blood flow, MRI, and blood/urine markers to track kidney stress during puberty. The team plans five years of annual follow-up to see if pubertal kidney changes predict how kidney health evolves in early adulthood and to uncover potential targets for early intervention. Results could inform monitoring strategies and treatments to prevent DKD progression in young people with diabetes.
Why it matters
Potential benefit: If successful, the study could lead to earlier detection of kidney problems in youths with diabetes and guide interventions to protect kidney health through puberty and beyond.
How similar studies have gone: Previous work showed puberty-related kidney changes in youth with diabetes; this renewal aims to confirm and extend these findings in a larger, longer-term cohort.
Where this research is happening
-
Seattle Children's Hospital
Seattle, United States Active
Researchers
- Principal investigator: Bjornstad, Petter — Seattle Children's Hospital
- Study coordinator: Bjornstad, Petter
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.