NIH-funded research NIH-funded research

Native-led health research center to improve pain, substance use, and mental health

Official title: Absentee Shawnee Tribal Health System: HEAL Initiative: Native Collective Research Effort to Enhance Wellness (N CREW) Program- Addressing Overdose, Substance Use, Mental Health, and Pain (OT2)

Funded at Absentee Shawnee Tribe of Oklahoma · NIH-11539109 · Data updated 2026-11-12

A tribally owned clinical research center is being built to understand and improve chronic pain and related substance use and behavioral health issues in the Absentee Shawnee community.

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Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionAbsentee Shawnee Tribe of Oklahoma
NIH-funded
Lab location1 site (Shawnee, United States)
Project startAugust 1, 2024
Project endMarch 31, 2027
Funding year2026
Award (this year)$198,005
NIH project number3OT2DA061113-01S2
Project IDNIH-11539109 on NIH RePORTER

Who could benefit from this research

Could help

Individuals within the Absentee Shawnee community experiencing chronic pain, substance use, or behavioral health challenges who seek care at AST clinics.

Less likely to help

Non-community members or individuals without access to AST clinics may not directly benefit.

What this research studies

This project establishes the AST Clinical Research Center within the Absentee Shawnee Tribal Health System to study pain, substance use, and mental health from a Native-led perspective. It creates governance, a tribal research workforce, and a secure data infrastructure that respects Indigenous data sovereignty. A mixed-methods pilot will combine clinical data with community members’ experiences to identify gaps in care and guide improvements at AST clinics. The work aims to prepare the tribe to lead future intervention studies that align with community values and priorities.

Why it matters

Potential benefit: If successful, the project could lead to more culturally aligned care for chronic pain and related behavioral health issues in the Absentee Shawnee community.

How similar studies have gone: This approach combines tribal governance, Indigenous data sovereignty, and mixed-methods research, a relatively unique but increasingly supported model for tribal health improvement.

Where this research is happening

  • Absentee Shawnee Tribe of Oklahoma
    Shawnee, United States
    Active

Researchers

  • Principal investigator: Miller, Alicia L — Absentee Shawnee Tribe of Oklahoma
  • Study coordinator: Miller, Alicia L

Related research

Other NIH-funded projects on the same topics.

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.