Condition

HIV Prevention clinical trials and research

• 33Clinical trials
• 249NIH research projects
• 8Countries

Newest HIV Prevention clinical trials

All recruiting trials (33)

• Pharmacist-guided PEP/PrEP Access Using PEPPI Software

  This trial tests whether the PEPPI software helps pharmacists provide PEP/PrEP and helps patients access these HIV prevention options.

  Recruiting Empowerx INC · Del Mar, California · NCT07683117

• Feasibility of Online HIV Prevention Research for People Who Inject Drugs

  This study tests whether online recruitment and at-home HIV testing can be done reliably by and for people who inject drugs.

  Recruiting Montefiore Medical Center · The Bronx, New York · NCT07625917

• Host-led harm reduction for men who have sex with men who engage in chemsex in Bangkok

  This project will try a host-led harm reduction approach to reduce substance-related, sexual, mental health, and legal harms among men who have sex with men who engage in chemsex in Bangkok.

  Recruiting Institute of HIV Research and Innovation Foundation, Thailand · Pathum Wan, Bangkok · NCT07512869

• Transgender-tailored harm reduction and PrEP service for people who engage in chemsex in Bangkok

  This project will try a comprehensive harm-reduction service tailored for transgender and non-binary adults in Bangkok who engage in chemsex or substance use to increase PrEP use, reduce HIV/STIs, and address mental health and socio-legal needs.

  Recruiting Institute of HIV Research and Innovation Foundation, Thailand · Pathum Wan, Bangkok · NCT07512856

• See if PrEP Choice helps young people start and stick with HIV prevention methods

  This trial tests whether the PrEP Choice package helps 13-24 year-olds in the U.S. begin and continue using PrEP or DoxyPEP for HIV prevention.

  Recruiting at 6 sites Westat · San Francisco, California and 5 other locations · NCT07510048

• Adding sexual-pleasure conversations to harm reduction services for MSM and transgender people who do chemsex in Thailand

  This project will try using a 'Pleasuremeter' to guide sexual-pleasure conversations in harm reduction services for MSM and transgender people who engage in chemsex or substance use in Thailand to see if it improves sexual health, substance use, and related outcomes.

  Recruiting Institute of HIV Research and Innovation Foundation, Thailand · Pathum Wan, Bangkok · NCT07509853

• Mobile interventions to reduce HIV stigma and improve PrEP use for transgender women in Bangkok

  This project will test two mobile app-based programs to reduce HIV-related stigma and help HIV-negative transgender women aged 18–29 in Bangkok start and stick with PrEP.

  Recruiting at 3 sites Institute of HIV Research and Innovation Foundation, Thailand · Bangkok, Bangkapi and 2 other locations · NCT07509827

• Developing transgender-tailored chemsex harm-reduction services in Thailand

  This project will try to understand chemsex experiences among transgender adults in Thailand to help design harm-reduction services that meet their needs.

  Recruiting Institute of HIV Research and Innovation Foundation, Thailand · Pathum Wan, Bangkok · NCT07505875

• Bringing long-acting lenacapavir PrEP to people who are unstably housed in Los Angeles County

  This project will try giving long-acting injectable lenacapavir as HIV prevention from UCLA's mobile health vans to adults who are unhoused or facing housing instability in Los Angeles County.

  Recruiting University of California, Los Angeles · Santa Monica, California · NCT07467018

• California MEPS Hub for HIV prevention and reentry support

  This project will test a peer-led, app-based program with small cash incentives to help people with substance use recently released from jail or prison get PrEP, HIV/STI testing, and related services.

  Recruiting at 3 sites University of California, Los Angeles · Oakland, California and 2 other locations · NCT07433985

• One-time double dose of Descovy (F/TAF) in healthy adults

  We will test a one-time double dose of two F/TAF (Descovy) tablets in healthy adults to see how long drug levels remain over 14 days for HIV PrEP.

  Recruiting Phase 1 Johns Hopkins University · Baltimore, Maryland · NCT07349758

• Unlocking PrEP: Peer health coaches to expand PrEP access during re-entry

  This project will try adding peer health coaches at a Dallas re-entry program to increase PrEP awareness and uptake among people with a history of justice involvement.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT07292792

• Digital PrEP Toolkit to help cisgender women in the Southeast access PrEP

  A Digital PrEP Toolkit is being tested to see if it helps cisgender women in Alabama and Mississippi learn about PrEP and start using it.

  Recruiting at 4 sites University of Alabama at Birmingham · Birmingham, Alabama and 3 other locations · NCT07292584

• PrEP Optimization Through Enhanced Continuum Tracking (PrOTECT AL)

  This project will test a real-time PrEP care dashboard and implementation strategies at seven Alabama clinics to see if they increase PrEP coverage and equity among people at risk for HIV.

  Recruiting University of Alabama at Birmingham · Birmingham, Alabama · NCT07231640

• Boosting long-acting injectable PrEP use among Latine gay/bisexual men and transgender women in the South

  This project will try giving long-acting injectable PrEP (lenacapavir) through a community clinic to Latine gay and bisexual men and transgender women in Durham to see if people stay on PrEP longer.

  Recruiting Phase 4 Duke University · Durham, North Carolina · NCT07218211

• Partner HIV self-testing kits plus PrEP support for HIV-negative new mothers

  This pilot will try giving partner HIV self-test kits plus counseling to help HIV-negative pregnant or postpartum women and their male partners in KwaZulu-Natal use HIV self-testing and start PrEP when needed.

  Recruiting Massachusetts General Hospital · Durban, KwaZulu-Natal · NCT07194902

• DynamiCare-based program to support re-entry for stimulant users at risk for HIV

  This study tests whether adding the DynamiCare mobile app plus patient navigation helps people released from justice settings who use stimulants to start HIV care (ART/PrEP) and reduce stimulant use.

  Recruiting at 2 sites University of Texas Southwestern Medical Center · New Haven, Connecticut and 1 other locations · NCT07136363

• Helping adolescent males talk with trusted adults about sexual health and HIV prevention

  This project will try a program to help 14–17-year-old males who have sex with males talk with trusted adults, find a trusted adult if needed, and learn ways to protect their sexual health while keeping privacy.

  Recruiting Rhode Island Hospital · Providence, Rhode Island · NCT07011563

• Intervention to improve PrEP use among Black men who have sex with men

  This study is testing a new support program to help Black men who have sex with men start and stick with PrEP to prevent HIV.

  Recruiting at 3 sites Brown University · Atlanta, Georgia and 2 other locations · NCT06872307

• Behavioral therapy to improve HIV prevention in sexual minority individuals

  This study is testing a new therapy to see if it can help sexual minority individuals reduce drug use and risky sexual behaviors while sticking to their HIV prevention medication.

  Recruiting The University of Texas Health Science Center at San Antonio · San Antonio, Texas · NCT06745947

• Increasing HIV prevention access for Black women

  This study is testing a new way to help Black women in Baltimore start taking HIV prevention medication by providing support and resources to overcome challenges they face.

  Recruiting Johns Hopkins Bloomberg School of Public Health · Baltimore, Maryland · NCT06703060

• Creating a decision-making tool for transgender women to choose HIV prevention methods

  This study is testing a new digital tool called WePrEP to help transgender women choose the best HIV prevention options, including a new injectable treatment, while improving conversations with their healthcare providers.

  Recruiting University of Colorado, Denver · Sheridan, Colorado · NCT06656676

• Using PrEP, Doing It for Ourselves (UPDOs)

  This project will test whether UPDOs, an online video and telehealth program paired with salon outreach, helps Black cisgender women in the southeastern US learn about and start using PrEP.

  Recruiting Duke University · Durham, North Carolina · NCT06638892

• Testing a gender-inclusive program for HIV prevention

  This study is testing a new HIV prevention program that uses text messages to help trans girls and nonbinary youth aged 14-18 learn how to protect themselves from HIV.

  Recruiting Center for Innovative Public Health Research · San Clemente, California · NCT06586151

• Improving HIV prevention for postpartum women in Malawi

  This study tests a new approach to help new mothers in Malawi prevent HIV by combining testing and treatment with their baby's vaccination visits and support from their partners and community.

  Recruiting University of North Carolina, Chapel Hill · Lilongwe · NCT06506188

• A new model to prevent mother-to-child HIV transmission in Malawi

  This study is testing a new community-based approach called the PAC-Man model to see if it can better prevent the spread of HIV from mothers to their babies in Malawi compared to standard care.

  Recruiting at 2 sites University of North Carolina, Chapel Hill · Lilongwe, Central Region and 2 other locations · NCT06493357

• Post-Injectable Cabotegravir PrEP to ART Transition: See if a TLD regimen works for people starting HIV treatment after prior Cabotegravir-Long-acting PrEP

  This study tests if a standard TLD regimen can effectively control HIV in people who recently used Cabotegravir-Long-acting PrEP and are starting first-line ART.

  Recruiting at 3 sites Phase 4 University of Witwatersrand, South Africa · Johannesburg, Gauteng and 2 other locations · NCT06485154

• Assessing HIV prevention methods during pregnancy and breastfeeding

  This study is testing whether a long-acting injectable HIV prevention method is safer than a daily pill for pregnant women and their babies in Malawi.

  Recruiting Phase 4 University of North Carolina, Chapel Hill · Lilongwe · NCT06158126

• Chatbot to boost PrEP use among Black MSM in the Southern United States

  A chatbot is being tested to raise PrEP awareness and help Black men who have sex with men in the U.S. South start and continue PrEP.

  Recruiting at 4 sites Yale University · Miami, Florida and 3 other locations · NCT05968755

• Increasing PrEP uptake among Latino men who have sex with men in Puerto Rico

  This study is trying out a new way to encourage Latino men who have sex with men in Puerto Rico to use PrEP, a medication that helps prevent HIV, by addressing their concerns and barriers to access.

  Recruiting University of Puerto Rico · San Juan · NCT05804461

• Understanding HIV prevention preferences among cisgender women and trans individuals

  This study is trying to understand what cisgender women and trans individuals think about HIV prevention methods like PrEP and how their choices affect their health.

  Recruiting Columbia University · New York, New York · NCT05165745

• Home self-collection of blood samples for HIV monitoring

  This study is testing if people with HIV can successfully collect their own blood samples at home to check how well their treatment is working.

  Recruiting University of Colorado, Denver · Aurora, Colorado · NCT04979728

• Cohort study on HIV prevention in France

  This study looks at how well different HIV prevention methods work in France by gathering information from people getting tested and treated for HIV and related infections.

  Recruiting at 31 sites DatAids · Belfort and 30 other locations · NCT03795376

NIH-funded research (newest 40 of 249)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Making HIV prevention and care easier for Ugandan youth

  A Ugandan study is testing ways to help adolescents and young adults (15–24) prevent HIV and stay healthy, using long-acting PrEP and youth-friendly services.

  NIH research Mu-Jhu Care · Kampala, Uganda · NIH-11644400

• Innovative HIV Prevention and Care Interventions for Adolescents and Young Adults in Uganda

  A Ugandan research team is testing practical, youth-focused strategies to help 15-24 year-olds using HIV prevention or treatment services stay healthy and engaged in care.

  NIH research Mu-Jhu Care · Kampala, Uganda · NIH-11644068

• Adolescent girls in Uganda: a long-term look at how money empowerment and family support affect HIV prevention, care, and mental health

  A long-term study in rural Uganda will test whether an intervention that combines economic empowerment and family strengthening can help HIV-negative and HIV-affected adolescent girls move safely into young adulthood.

  NIH research New York University · New York, United States · NIH-11624010

• Long-term HIV prevention and mental health support for adolescent girls and young women in Uganda

  A long-term program in rural Uganda tests if combining economic support and family strengthening helps teenage girls stay HIV-free and improve mental health as they grow into young adults.

  NIH research New York University · New York, United States · NIH-11624009

• Harnessing male peer networks to boost HIV testing and PrEP use

  A large clinical trial in South Africa tests whether giving HIV self-test kits through male peer networks, with phone support, increases PrEP uptake among men.

  NIH research Stellenbosch University · Stellenbosch, SOUTH AFRICA · NIH-11621079

• Harnessing men's peer networks to boost HIV self-testing and PrEP use

  A large project in South Africa tests whether giving HIV self-test kits through men’s social networks, with phone support, can lead to more men starting PrEP and using HIV testing.

  NIH research Stellenbosch University · Stellenbosch, SOUTH AFRICA · NIH-11621078

• Couples-based decision aid to improve HIV prevention choices for women in Uganda

  A study tests a couples-focused decision tool to help Ugandan women choose the best HIV prevention option with input from partners.

  NIH research Research Triangle Institute · Research Triangle Park, United States · NIH-11593444

• TB PrEP: Bringing HIV prevention to households affected by TB in Uganda

  Aims to help people in households with TB in Uganda access HIV PrEP as part of a combined prevention approach.

  NIH research University of Washington · Seattle, United States · NIH-11590744

• How choosing PrEP products could improve HIV protection for young women in Kenya

  This project looks at which HIV-prevention options young Kenyan women prefer and how choosing a product affects how well they stay protected.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11572510

• Effectiveness of PrEP product choice for HIV prevention among young Kenyan women seeking reproductive health services

  A study tests which PrEP options best help young Kenyan women stay protected against HIV when they access reproductive health services.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11572509

• Improving HIV Prevention and Substance Use Care after Sexual Assault for Adolescents and Young Adults

  A pilot study aims to make HIV prevention and substance use support more available for teens and young adults who have experienced sexual violence.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11565537

• Improving HIV Prevention for Women in ObGyn Care

  Aimed at helping women in obstetric/gynecologic care reduce their risk of HIV by making PrEP and risk–screening more accessible and acceptable.

  NIH research Thomas Jefferson University · Philadelphia, United States · NIH-11560874

• Precision HIV Prevention for Youth: Building a Youth Learning Health Community

  A youth-focused approach uses data and community engagement to improve HIV prevention interventions in North Florida.

  NIH research Florida State University · Tallahassee, United States · NIH-11556648

• Ways to boost HIV prevention uptake for adults at drinking venues in East Africa

  A study exploring a new approach to help adults at risk for HIV in Kenya and Uganda start and keep using HIV prevention tools like PrEP and PEP, by engaging them in drinking venues.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11553387

• Strategies to boost HIV prevention uptake at drinking venues in Kenya and Uganda

  A research project tests new ways to help adults at high risk for HIV use PrEP/PEP and stay engaged in prevention services, by working with people in alcohol-serving venues in Kenya and Uganda.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11553386

• Global HIV Prevention and Treatment Clinical Trials Unit at UNC

  A UNC program dedicated to advancing HIV prevention and treatment through international clinical trials, engaging patients and communities affected by HIV in the US and globally.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11540398

• Hybrid approach to peer-supported mood and incentive program to reduce HIV risk among women who inject drugs

  A pilot program tests a combined peer-supported mood-boosting approach with contingency management to help stimulant-using women who inject drugs reduce HIV risk.

  NIH research Wake Forest University Health Sciences · Winston-Salem, United States · NIH-11537936

• Adaptation of a proven HIV prevention approach to help Ghanaian young men increase HIV self-testing

  A project adapts a well-known HIV prevention program to help young men in Ghana’s slums learn about and use HIV self-testing, aiming to reduce stigma and improve access to testing.

  NIH research University of Rochester · Rochester, United States · NIH-11526486

• Suubi4HER: Long-term impact of a combined program for HIV prevention, care and mental health in Ugandan adolescent girls and young women

  A long-term study in Uganda will test whether a combined economic empowerment and family-strengthening program helps HIV prevention, care, and mental health among adolescent girls as they become young women.

  NIH research New York University · New York, United States · NIH-11518189

• Peer-led HIV prevention choices for women at high risk in Uganda

  This program helps women at higher risk of HIV in Uganda work with peer supporters to choose and keep using prevention options like pills, long‑acting injections, or a vaginal ring.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11509060

• HIV Prevention Trials Network: Data and Analytics Support

  This grant supports a national network working to find safe, scalable HIV prevention options for people at risk around the world.

  NIH research Fred Hutchinson Cancer Center · Seattle, United States · NIH-11507071

• Proyecto VIDA: A long-term study on HIV prevention and engagement among MSM in Colombia

  A large online-based study in Colombia will follow 5,000 HIV-negative men who have sex with men for three years to understand HIV risk, PrEP use, and care engagement.

  NIH research Graduate School of Public Health and Health Policy · New York, United States · NIH-11502824

• Nurse-led group program to boost PrEP use for women at risk of HIV

  A nurse-developed, three-session group program helps women in midwestern cities start and stay on PrEP to prevent HIV.

  NIH research University of Illinois at Chicago · Chicago, UNITED STATES · NIH-11485334

• Advancing pharmacy-based delivery of STI and HIV prevention for cisgender women

  A study in Kenya and similar settings explores using pharmacies to deliver STI prevention and HIV prevention tools to young cisgender women.

  NIH research University of Washington · Seattle, United States · NIH-11478494

• Nationwide rollout of an HIV prevention program for Bahamian youth

  A team is expanding an evidence-based HIV prevention program for Bahamian students and families to reach more schools and ensure teachers implement it well.

  NIH research Univ of Massachusetts Med Sch Worcester · Worcester, United States · NIH-11478468

• Improving HIV Prevention and Care for Ugandan Adolescents and Young Adults

  A Uganda-based research effort aims to boost HIV prevention and care outcomes for 15-24 year-olds by testing practical, community-based strategies to increase PrEP use and viral suppression.

  NIH research Mu-Jhu Care · Kampala, Uganda · NIH-11478467

• Adolescent and Youth HIV Prevention and Care Improvements in Uganda

  A UG1 grant is testing ways to help Ugandan teens and young adults (ages 15-24) prevent HIV and stay healthy if they have HIV, using new long-acting PrEP and community care approaches.

  NIH research Mu-Jhu Care · Kampala, Uganda · NIH-11478466

• Malkia Klabu: safer, youth-friendly pharmacies to boost HIV prevention for AGYW in Tanzania

  A Tanzania-based project tests a youth-friendly pharmacy model to improve access to HIV prevention and sexual health services for adolescent girls and young women.

  NIH research Centre of Excellence in Health Monitoring and Evaluation · Morogoro, Tanzania U Rep · NIH-11478457

• CAB-LA PrEP for breastfeeding women after delivery in Botswana

  This study tests a long-acting HIV prevention shot for new mothers who are breastfeeding in Botswana to see if it prevents HIV safely and effectively.

  NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-11478445

• Adolescent consent for HIV prevention in Rakai, Uganda

  This project works with teens in Rakai, Uganda to find better ways for them to understand and give permission to take part in HIV prevention work and to learn about oral and injectable PrEP.

  NIH research Graduate School of Public Health and Health Policy · New York, United States · NIH-11471078

• SMART: a program to help people who use drugs in Atlanta stay on HIV prevention and treatment

  A new program aims to help people who use drugs in Atlanta, especially those who are unhoused or unstably housed, stay connected to HIV prevention and treatment and related services.

  NIH research Florida State University · Tallahassee, United States · NIH-11470972

• Integrated HIV Prevention for Women in Supervision Programs in the Deep South

  A new, tailored HIV prevention program for Black women in Alabama who are under probation, parole, or similar supervision, using E-WORTH South to reduce sexual risk and increase access to prevention.

  NIH research University of Georgia · Athens, United States · NIH-11470921

• Coordinating center for new HIV prevention tools and strategies

  This project runs clinical trials to bring new HIV prevention options to people at risk worldwide, including young people, women, men who have sex with men, transgender women, sex workers, and people who inject drugs.

  NIH research Family Health International · Durham, United States · NIH-11466553

• HIV prevention network and operations center

  This program develops and runs new HIV prevention tools—like long‑acting medicines, combined HIV/contraception products, and antibodies—for people at higher risk such as young adults, women in sub‑Saharan Africa, men who have sex with men, transgender women, sex workers, and people who inject drugs.

  NIH research Family Health International · Durham, United States · NIH-11466552

• HIV prevention network coordinating center

  This program runs and supports studies of new long-acting HIV prevention medicines and combined products for people at risk, including young adults, men who have sex with men, transgender women, sex workers, and people who inject drugs.

  NIH research Family Health International · Durham, United States · NIH-11466551

• Healthy Choices Implementation Trial for Young Adults with HIV and Alcohol Use

  A nationwide study tests different ways to spread a proven program that helps 18–29 year-olds reduce alcohol use and HIV risk, while supporting HIV prevention and treatment adherence.

  NIH research Florida State University · Tallahassee, United States · NIH-11464945

• HIV prevention and treatment clinical trials unit at UNC

  A UNC-led program coordinates HIV prevention and treatment clinical trials across multiple sites to help people with HIV and those at risk, including diverse populations in the US and abroad.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11458534

• HIV Prevention and Treatment Clinical Trials Unit at UNC

  A UNC-led program will run multiple HIV prevention and treatment trials across the US and other regions to improve care for people living with HIV and those at risk.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11458533

• HOPE in Kyrgyzstan prisons: a kim of real-world help for people at risk of HIV

  A prison-based program called HOPE aims to help HIV prevention by boosting access to treatment and reducing stigma among inmates at high risk of HIV in Kyrgyzstan.

  NIH research Yale University · New Haven, United States · NIH-11455252

• HOPE: A prison-based program to boost HIV prevention for inmates in Kyrgyzstan

  A 6-week program called HOPE helps prisoners in Kyrgyzstan learn about HIV, manage mental health, and build skills to access HIV prevention services like medications and clean needles.

  NIH research Yale University · New Haven, United States · NIH-11455251

Related topics

Quick answers

How many HIV Prevention clinical trials are recruiting right now?

33, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 8 countries. The most sites are in United States (21 trials), Thailand (5 trials), Malawi (3 trials), South Africa (2 trials), Puerto Rico (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 3, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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