Condition

Pulmonary Disease clinical trials and research

• 14Clinical trials
• 51NIH research projects
• 10Countries

Newest Pulmonary Disease clinical trials

All recruiting trials (14)

• How team organization affects patient experience in pulmonary rehabilitation in Türkiye

  This project will ask adults in Türkiye who completed pulmonary rehabilitation to see if different program team setups are linked to their satisfaction.

  Recruiting Saglik Bilimleri Universitesi · Istanbul, Üsküdar · NCT06998550

• Using breath analysis for quick diagnosis of respiratory diseases

  This study is testing a new way to quickly diagnose respiratory diseases by analyzing the breath of patients on ventilators to see if it can help detect problems earlier.

  Recruiting Oregon Health and Science University · Portland, Oregon · NCT06775106

• Building a multiomic database using advanced imaging techniques

  This study is trying to build a big database using advanced imaging techniques to see how different health information can help better understand and prevent diseases in adult patients.

  Recruiting IRCCS San Raffaele · Milan · NCT06523270

• Rehabilitation program for patients with chronic diseases

  This study is testing a rehabilitation program to see if it helps people with long-term illnesses like cancer and heart disease feel better and improve their overall health.

  Recruiting at 2 sites Insel Gruppe AG, University Hospital Bern · Heiligenschwendi, Canton of Bern and 1 other locations · NCT06516172

• Registry for adults with severe asthma receiving biologic treatments in Taiwan

  This study is tracking adults with severe asthma in Taiwan who are using biologic treatments to see how well they work and what factors might help choose the best options.

  Recruiting Taichung Veterans General Hospital · Taichung · NCT06456450

• Registry and biorepository for pulmonary imaging

  This study is trying to collect images and samples from people using new lung imaging techniques to see how they can help us understand and improve lung health.

  Recruiting University of Kansas Medical Center · Kansas City, Kansas · NCT05530408

• Using stem cells from umbilical cords to treat lung diseases

  This study is testing if a single infusion of stem cells from umbilical cords can help people with lung diseases like asthma and COPD feel better and improve their health over time.

  Recruiting at 2 sites Phase 1 The Foundation for Orthopaedics and Regenerative Medicine · Naples, Florida and 1 other locations · NCT05147688

• Non-drug therapy for controlling cough in patients with lung disease

  This study is testing a new non-drug therapy to help adults with interstitial lung disease and a long-lasting cough feel better when combined with pulmonary rehabilitation.

  Recruiting at 2 sites West Park Healthcare Centre · Hamilton, Ontario and 1 other locations · NCT04767074

• SPECT-guided radiation that spares well-functioning lung during curative lung cancer treatment

  This trial will test whether using perfusion SPECT/CT to guide radiation plans that avoid highly functional lung reduces radiation-related lung damage for adults receiving curative chemo-radiation for lung cancer.

  Recruiting at 2 sites University of Aarhus · Sydney, New South Wales and 1 other locations · NCT04676828

• Pembrolizumab plus lenvatinib for HPV-related recurrent respiratory papillomatosis with lung involvement

  This research will try pembrolizumab together with lenvatinib in adults who have HPV-associated recurrent respiratory papillomatosis that involves the lungs.

  Recruiting Phase 2 Yale University · New Haven, Connecticut · NCT04645602

• Pulmonary rehabilitation for adults on high-flow oxygen

  This test checks whether adding pulmonary rehabilitation helps adults in the ICU who are receiving high-flow humidified oxygen support.

  Recruiting Chinese PLA General Hospital · Beijing, Beijing Municipality · NCT04441151

• Evaluating lung therapies for patients after heart surgery

  This study tests three different breathing therapies to see which one helps patients recover their lung function best after heart surgery.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT04164173

• Observing the progression of pulmonary arterial hypertension

  This study is tracking how pulmonary arterial hypertension changes over time in patients and healthy volunteers to find new ways to treat it.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT01730092

• Examining Lung Proteins in Patients with Pneumonia

  This study is testing lung fluid samples from pneumonia patients to see if certain proteins can help identify the causes of their lung issues and improve treatment options.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT00077909

NIH-funded research (newest 40 of 51)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Ethics-aware Multimodal AI for COPD prevention, diagnosis, and treatment

  A broad AI model uses diverse health data to help predict and manage COPD in people, with an emphasis on ethics and fairness.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11573170

• New regimens to treat MAC lung disease in people with lung problems or weak immune systems

  A study from Johns Hopkins aims to test new drug combinations to treat MAC lung disease in people with damaged lungs or weakened immune systems.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11572320

• Positive airway pressure therapy for older veterans with COPD and sleep apnea overlap

  A plan to see if using a CPAP/BAP therapy improves sleep, thinking, and quality of life for older veterans who have both COPD and sleep apnea.

  NIH research John D Dingell VA Medical Center · Detroit, United States · NIH-11415408

• Understanding how microbes and our bodies shape HIV-related COPD in LMICs

  This project looks at how interactions between the human body and microbes may influence COPD in people living with HIV in low- and middle-income countries.

  NIH research Duke University · Durham, United States · NIH-11404969

• Anti-EMAP II antibody as a first-in-class treatment for COPD-related pulmonary hypertension

  A first-in-class antibody treatment is being developed to help people with COPD-related pulmonary hypertension by blocking EMAP II, a molecule involved in lung injury and inflammation.

  NIH research Allinaire Therapeutics, LLC · Cleveland, United States · NIH-11403849

• Non-coding RNA and COPD: how RNA structure changes with disease

  A COPD research project explores how non-coding RNA structures in adults with COPD change due to genetic differences and how this affects gene activity.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11399913

• Patient-reported outcomes in lung disease due to non-tuberculous mycobacteria

  This grant funds research to understand how NTM lung disease affects daily life by asking patients about symptoms and well-being during and after treatment.

  NIH research Oregon Health & Science University · Portland, United States · NIH-11383438

• ANT2 and mitochondrial dysfunction in COPD: how energy transport affects lung repair

  This project studies how a key mitochondrial transporter (ANT2) may drive aging-like cell changes and repair problems in the lungs of people with COPD.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11380637

• Predicting MAC-PD progression and treatment response with data and models

  A Mayo Clinic team is using patient data and computer models to predict how Mycobacterium avium complex pulmonary disease will progress and respond to antibiotic treatment.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11374503

• COPD in people with HIV: risks, care quality, and outcomes

  This effort looks at how chronic lung disease affects people living with HIV and how care quality relates to their outcomes.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11362714

• Role of viral infections and autoantibodies in COPD progression

  This research looks at how viral infections and autoimmune antibodies might be linked to faster lung function decline in people with COPD.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11330657

• RNA control networks in COPD

  This project looks at how proteins that control RNA affect lung cells in people with COPD.

  NIH research University of Virginia · Charlottesville, United States · NIH-11326208

• Immune cell 'nets' and inflammation in heart and lung scarring

  This project looks at how neutrophil 'nets' and inflammation help form blood clots and cause scarring in the heart and lungs.

  NIH research Boston Children's Hospital · Boston, United States · NIH-11300191

• Shorter all-oral treatments for Mycobacterium abscessus lung infections

  Developing shorter, all-oral drug combinations to better cure Mycobacterium abscessus lung infections and reduce treatment time and side effects.

  NIH research Hackensack University Medical Center · Hackensack, United States · NIH-11261782

• Blood test to detect MAC DNA for faster diagnosis and monitoring of lung infection

  A very sensitive CRISPR-based blood test to find Mycobacterium avium complex DNA that may help people with suspected or confirmed MAC lung infection get faster diagnosis and monitoring.

  NIH research Oregon Health & Science University · Portland, United States · NIH-11252363

• Genes that push lungs toward COPD or pulmonary fibrosis

  This work looks at how specific gene changes in lung cells might push people toward COPD or pulmonary fibrosis, especially among older adults and people who smoke or used to smoke.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11238928

• A new inhaler for delivering anti-inflammatory medication to help manage pain in COPD patients

  This study is testing a new, easy-to-use inhaler that delivers medicine directly to the deep parts of the lungs for people with COPD, aiming to help reduce inflammation and improve comfort.

  NIH research Scientific Horizons Consulting LLC · Irvine, UNITED STATES · NIH-11237357

• Muscle weakness from high carbon dioxide in COPD

  Looks at whether boosting muscle energy production helps people with COPD who retain too much carbon dioxide.

  NIH research Albany Medical College · Albany, United States · NIH-11235891

• Shorter, safer drug combinations for Mycobacterium avium lung disease

  This project tests new and repurposed antibiotic combinations to shorten and improve treatment for people with Mycobacterium avium complex (MAC) lung infections.

  NIH research University of Texas Hlth Ctr at Tyler · Tyler, United States · NIH-11228407

• Body-microbe links behind lung disease in people with HIV in low- and middle-income countries

  Researchers will use many types of biological measurements to find how microbes and immune responses contribute to lung disease in adults living with HIV in low- and middle-income countries.

  NIH research Duke University · Durham, United States · NIH-11197590

• Fungal leaks from the gut and lung health in COPD

  This project looks at whether fungi or fungal pieces that pass from the gut into the blood make COPD symptoms and lung function worse.

  NIH research Wake Forest University Health Sciences · Winston-Salem, United States · NIH-11194604

• Video Telehealth pulmonary rehab to cut COPD readmissions

  A telehealth pulmonary rehabilitation program delivered by video is being tested to help people with COPD stay out of the hospital.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11191546

• Mobile 1/2 Video Telehealth Pulmonary Rehab to Cut COPD Readmissions

  A remote pulmonary rehab program delivered via video aims to help people with COPD reduce hospital readmissions and improve daily living.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11191541

• Non-coding RNA changes in COPD

  Researchers are looking at how changes in the shapes of non-coding RNAs affect gene activity in adults with COPD.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11177640

• Symptoms and quality of life for people with non-tuberculous mycobacterial lung disease

  This project looks at how cough, fatigue, and daily life are affected in adults with non-tuberculous mycobacterial lung disease and whether patient reports line up with lab tests and cough recordings.

  NIH research Oregon Health & Science University · Portland, United States · NIH-11166697

• Investigating how pulmonary vascular disease affects breathing problems in COPD patients

  This study is looking at how lung blood vessel problems can affect breathing in people with COPD, and it hopes to find easier ways to spot these issues early on, so patients can get better care.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11142393

• Investigating how viral infections and autoantibodies affect lung disease progression

  This study is looking at how past viral infections and the body's immune responses might affect the worsening of Chronic Obstructive Pulmonary Disease (COPD) by examining blood samples from 3,000 people, to help us understand more about how COPD develops over time.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11139465

• Understanding and guiding treatment for M. avium lung disease

  This project aims to create tools that help doctors decide the best way to treat lung infections caused by Mycobacterium avium, so patients get the right care at the right time.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11136859

• Developing shorter and more effective oral treatments for lung infections caused by Mycobacterium abscessus

  This study is looking for new pill-based treatments for people with lung infections caused by a tough bacteria called Mycobacterium abscessus, aiming to make it easier and more comfortable for patients to get better without needing IVs.

  NIH research Hackensack University Medical Center · Hackensack, United States · NIH-11133092

• Predicting risk of chronic obstructive pulmonary disease using genetic information

  This study is looking at how your genes and environment can affect your chances of getting chronic obstructive pulmonary disease (COPD), so we can find out who might be at higher risk and help them get care sooner.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11059182

• Using CRISPR to quickly detect Mycobacterium avium complex DNA for diagnosing lung disease

  This study is testing a quick and easy way to use CRISPR technology to find Mycobacterium avium complex (MAC) DNA in the blood, which could help diagnose and monitor MAC lung disease without needing uncomfortable procedures, making it better for patients.

  NIH research Oregon Health & Science University · Portland, United States · NIH-11058534

• Parsnip compounds to help protect lungs in COPD

  This project will see whether natural compounds from parsnips can help protect the lungs of people with COPD linked to air pollution or smoking.

  NIH research Purdue University · West Lafayette, United States · NIH-11058085

• How inflammation and blood clots affect heart and lung diseases

  This study is looking at how certain immune responses, especially in older adults, can lead to heart and lung problems by causing inflammation and blood clots, and the researchers hope to find new ways to help treat these issues.

  NIH research Boston Children's Hospital · Boston, United States · NIH-11049092

• Understanding how RNA regulation affects Chronic Obstructive Pulmonary Disease

  This study is looking at how certain proteins that interact with RNA might affect the way your body handles Chronic Obstructive Pulmonary Disease (COPD), with the hope of finding new ways to understand and treat the condition.

  NIH research University of Virginia · Charlottesville, United States · NIH-11022330

• New treatments for lung disease caused by Mycobacterium abscessus

  This study is testing a new antibiotic called omadacycline to see if it can help older adults and people with lung problems who have a tough-to-treat infection caused by Mycobacterium abscessus, and we want to find out how well it works and if it's safe.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11011626

• Understanding genetic factors that help some people cope with chronic obstructive pulmonary disease (COPD)

  This study is looking at how your genes and other biological factors might help some people with COPD feel better and cope with their condition, so we can find ways to predict who might do well and improve care for everyone with COPD.

  NIH research Upstate Medical University · Syracuse, United States · NIH-11009987

• Understanding how immune responses affect flare-ups in chronic lung disease

  This study is looking at how a weakened immune system can lead to more frequent flare-ups in people with COPD, especially when infections from bacteria like Streptococcus pneumoniae occur, and it hopes to find ways to better identify and treat those at higher risk.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11004387

• Understanding how genetics influence the risk of chronic lung diseases like COPD and pulmonary fibrosis.

  This study is looking at how our genes might affect the risk of developing lung diseases like COPD and IPF, and it aims to find out how these genetic differences can help us create more personalized treatments for patients.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11001125

• Understanding the financial challenges faced by patients with chronic obstructive pulmonary disease (COPD)

  This study is looking at how the high costs of treating COPD, like inhalers and hospital visits, affect patients' health and ability to stick to their treatment plans, and it aims to find ways to help ease these financial struggles.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-10998008

• New treatment options for Mycobacterium avium lung disease

  This study is looking for better and quicker ways to treat lung infections caused by Mycobacterium avium complex (MAC) by testing different combinations of antibiotics, so patients can get healthier faster with less time on medication.

  NIH research University of Texas Hlth Ctr at Tyler · Tyler, United States · NIH-10997350

Related topics

Quick answers

How many Pulmonary Disease clinical trials are recruiting right now?

14, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 10 countries. The most sites are in United States (7 trials), Switzerland (1 trial), Taiwan (1 trial), Turkey (Türkiye) (1 trial), Greece (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 1, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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