Condition

Cough clinical trials and research

• 16Clinical trials
• 11NIH research projects
• 13Countries

Newest Cough clinical trials

All recruiting trials (16)

• Remifentanil With or Without Lidocaine for Extubation After Thyroid Surgery

  This study tests whether adding intravenous lidocaine to remifentanil during awakening reduces coughing after thyroidectomy extubation in adults.

  Recruiting Phase 4 Pamukkale University · Denizli · NCT07857356

• Oliceridine vs Sufentanil for cough during anesthesia induction

  This trial tests whether oliceridine is better than sufentanil at reducing cough during anesthesia induction in adults undergoing elective surgery.

  Recruiting Phase 4 Shanghai Pulmonary Hospital, Shanghai, China · Tianmen, Hubei · NCT07660380

• Combined acupressure to reduce post-thoracotomy pain and improve lung volume

  This trial will try combined acupressure on patients after thoracotomy to see if it reduces postoperative pain and helps restore lung volume.

  Recruiting Dogus Universitesi · Istanbul · NCT07411417

• Two CE‑marked throat sprays for adults with a recent dry or productive cough

  This study will try two CE‑marked throat sprays to see if adults with a recent viral cough tolerate them well and get symptom relief.

  Recruiting Phase 4 University Hospital, Clermont-Ferrand · Clermont-Ferrand · NCT07330856

• Rengalin liquid for dry cough in children aged 6 months to 3 years

  This will test whether Rengalin liquid reduces dry cough in children 6 months to 3 years old with acute viral upper respiratory infections.

  Recruiting at 22 sites Phase 3 Materia Medica Holding · Gatchina and 29 other locations · NCT07171099

• Mechanism-guided treatment versus proton-pump inhibitor therapy for chronic throat symptoms

  This trial will test whether a mechanism-guided approach combining personalized acid-suppression and voice therapy helps adults (18–89) with chronic throat symptoms more than usual proton pump inhibitor (PPI) treatment.

  Recruiting Phase 4 University of California, San Diego · San Deigo, California · NCT06999577

• Cough control with dexmedetomidine, magnesium sulfate, or lidocaine after general anesthesia

  This study will see if dexmedetomidine, magnesium sulfate, or lidocaine reduces how often and how hard adults cough while waking from general anesthesia.

  Recruiting Phase 3 Al-Azhar University · Asyut · NCT06979141

• Creating a questionnaire to assess cough control

  This study is trying to create a new questionnaire to help people with chronic cough share how well their cough is controlled and see if treatments are working.

  Recruiting King's College Hospital NHS Trust · London · NCT06918756

• Investigating the link between cough and hemorrhoids

  This study is trying to see if having a cough might be linked to developing hemorrhoids in patients visiting the hospital for this condition.

  Recruiting Muğla Sıtkı Koçman University · Muğla, Menteşe · NCT06878209

• Observing symptoms in children with first-onset bronchial asthma

  This study looks at how asthma shows up in kids and teens aged 3 to 18, especially if they have unusual symptoms like a chronic cough, to see if a specific questionnaire can help spot these cases better.

  Recruiting Charles University, Czech Republic · Prague · NCT06201494

• Improving learning of a cough assistance technique in children

  This study is testing if a fun coaching program can help children, both healthy and those with neuromuscular diseases, learn a special cough technique better than just regular guidance from a physiotherapist.

  Recruiting Cliniques universitaires Saint-Luc- Université Catholique de Louvain · Brussels, Brussels Capital · NCT06190431

• Validation of a cough monitoring system

  This study is testing a new wearable device that tracks coughs in patients aged 2 and older to see if it can help doctors better understand and manage respiratory issues.

  Recruiting at 7 sites Cough Monitoring Medical Solutions · Alfena and 7 other locations · NCT05989698

• Using larynx stimulation to treat chronic cough

  This study is testing a new way to help adults with chronic cough feel better by using gentle vibrations on their voice box to see if it reduces their coughing.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT05273190

• Non-drug therapy for controlling cough in patients with lung disease

  This study is testing a new non-drug therapy to help adults with interstitial lung disease and a long-lasting cough feel better when combined with pulmonary rehabilitation.

  Recruiting at 2 sites West Park Healthcare Centre · Hamilton, Ontario and 1 other locations · NCT04767074

• Injection treatment for chronic cough relief

  This study is testing a new injection treatment for people with chronic cough caused by nerve irritation to see if it can help reduce their cough and improve their symptoms.

  Recruiting University of Alabama at Birmingham · Birmingham, Alabama · NCT04642352

• National cohort of children with respiratory issues in Switzerland

  This study looks at children in Switzerland with breathing problems to see how these issues affect their health and treatment over time.

  Recruiting at 9 sites University of Bern · Vienna and 11 other locations · NCT03505216

NIH-funded research (11)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Behavioral cough suppression and capsaicin for refractory chronic cough

  A multi-site study will test how a behavioral therapy for stopping cough works alone and with capsaicin to help people with stubborn chronic cough.

  NIH research University of Montana · Missoula, United States · NIH-11418499

• Vibrotactile stimulation to help people with chronic cough that doesn’t respond to treatment

  A study tests a vibrating stimulation device for the voice box to help people with stubborn chronic cough feel better and cough less.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11395500

• Understanding how cough spreads tuberculosis

  This study is looking at how coughing helps spread the bacteria that cause tuberculosis (TB) so we can find better ways to prevent and treat the disease, especially for those at higher risk.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-11308397

• Understanding and preventing lung problems after tuberculosis treatment

  This research aims to find new ways to identify people who are at risk of developing long-term lung issues after completing treatment for tuberculosis.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11194314

• Gentle throat vibration therapy for stubborn chronic cough

  This project uses gentle vibration applied to the throat to try to reduce long-lasting cough in people whose cough hasn't improved with usual treatments.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11170705

• Finding the best treatments for chronic cough

  This project aims to help doctors choose the most effective treatment for people with chronic cough by understanding what makes each person respond differently.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11162507

• Understanding how tuberculosis bacteria cause cough and spread

  This study is looking at how the bacteria that cause tuberculosis can make people cough, which helps them spread the infection, and it aims to find out how this happens so we can better control the disease.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11030724

• Understanding how to better treat chronic coughing in patients with cough hypersensitivity syndrome.

  This study is looking at ways to help people with cough hypersensitivity syndrome (CHS) by figuring out which treatments, like medications or therapy, work best for different individuals, so you can get the right help without the guesswork.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-10985323

• Using vibrations on the larynx to help with chronic cough

  This study is testing a new way to help people with chronic coughs that don’t get better with regular treatments, using gentle vibrations on the throat to see if it can reduce coughing and make life more comfortable.

  NIH research University of Minnesota · Minneapolis, United States · NIH-10950386

• Identifying patients at risk of lung disease after tuberculosis treatment

  This study is looking for ways to help people who have finished their tuberculosis treatment by finding out who might develop lung problems later on, using new tools like a mobile app to track coughs instead of just relying on standard lung tests.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-10891638

• Using spinal cord stimulation to help people with spinal cord injuries cough

  This study is looking at how spinal cord stimulation can help people with neck and upper back injuries regain their ability to cough, which can make it easier for them to clear their airways and stay healthy.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-10707886

Related topics

Quick answers

How many Cough clinical trials are recruiting right now?

16, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 13 countries. The most sites are in United States (3 trials), Turkey (Türkiye) (3 trials), Belgium (1 trial), Portugal (1 trial), Czechia (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 4, Phase 3: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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