Understanding how genetics influence the risk of chronic lung diseases like COPD and pulmonary fibrosis.
Uncovering the genetically-driven differential susceptibility to chronic obstructive pulmonary disease and pulmonary fibrosis
This study is looking at how our genes might affect the risk of developing lung diseases like COPD and IPF, and it aims to find out how these genetic differences can help us create more personalized treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11001125 on NIH RePORTER |
What this research studies
This research investigates the genetic factors that contribute to the differing risks of chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF), two serious lung conditions. By analyzing genetic variants identified in previous studies, the researchers aim to uncover how these variants function as 'molecular switches' that influence disease development. The study will utilize advanced techniques, including CRISPR technology, to explore the underlying mechanisms and identify the specific lung cell types affected by these genetic factors. Patients may benefit from insights that could lead to more personalized treatment approaches based on their genetic profiles.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with chronic obstructive pulmonary disease or idiopathic pulmonary fibrosis, particularly those with a family history of these conditions.
Not a fit: Patients with other unrelated respiratory conditions or those without a genetic predisposition to COPD or IPF may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with COPD and pulmonary fibrosis.
How similar studies have performed: Previous genome-wide association studies have successfully identified genetic loci associated with COPD, suggesting that this approach has potential for uncovering new insights into disease mechanisms.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Cho, Michael H. — Brigham and Women's Hospital
- Study coordinator: Cho, Michael H.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.