Predicting MAC-PD progression and treatment response with data and models
Official title: Systems biology to predict progression and treatment response in M avium complex pulmonary disease
Funded at Mayo Clinic Rochester · NIH-11374503 · Data updated 2026-11-12
A Mayo Clinic team is using patient data and computer models to predict how Mycobacterium avium complex pulmonary disease will progress and respond to antibiotic treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | July 11, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $738,217 |
| NIH project number | 5R01AI172838-03 |
| Project ID | NIH-11374503 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults diagnosed with MAC-PD who may be managed with observation or with antibiotics could participate through data sharing and future clinical decisions.
✕Less likely to help
Patients not affected by MAC-PD or those not involved in data-sharing or prospective cohorts may not benefit.
What this research studies
This project combines clinical data, immune information, and drug data from past and current MAC-PD patients. Researchers will build machine learning tools and computer simulations to create a disease progression risk score for patients managed without antibiotics, and a treatment failure risk score for those on standard antibiotic regimens. The goal is to help doctors decide who needs closer monitoring or intensified treatment, reducing unnecessary drug exposure and side effects. If successful, these risk scores could personalize care and shorten ineffective treatments for MAC-PD.
Why it matters
Potential benefit: If the risk scores work well, patients could receive more tailored care that improves outcomes and reduces unnecessary antibiotic exposure.
How similar studies have gone: Previous studies in other lung infections have used ML and mechanistic models to forecast progression, but this project applies it specifically to MAC-PD.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Escalante, Patricio — Mayo Clinic Rochester
- Study coordinator: Escalante, Patricio
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.