Clinical trial Recruiting at 2 sites Interventional Ages 18 to 85

Non-drug therapy for controlling cough in patients with lung disease

Official title: A Non-pharmacological Cough Control Therapy as an Adjuvant of Pulmonary Rehabilitation in People With Interstitial Lung Diseases and Chronic Cough - A Feasibility Study

Run by West Park Healthcare Centre · NCT04767074 · Data updated 2026-11-12

This study is testing a new non-drug therapy to help adults with interstitial lung disease and a long-lasting cough feel better when combined with pulmonary rehabilitation.

More Pulmonary Fibrosis trials

Quick facts

Study typeInterventional
Ages18 Years to 85 Years
SexAll
Enrollment24 (estimated)
SponsorWest Park Healthcare Centre
Academic / other
Locations2 sites (Hamilton, Ontario and 1 other locations)
StatusRecruiting
StartedSeptember 1, 2020
Main results expectedDecember 2025
Study endsDecember 2025
Registry record updatedApril 3, 2025
Trial IDNCT04767074 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adults diagnosed with any form of interstitial lung disease and experiencing a chronic cough for over eight weeks.

Probably not a fit

Patients with significant sputum production, recent respiratory exacerbations, or other conditions that hinder exercise training may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates a non-pharmacological cough control therapy aimed at treating chronic cough in patients with interstitial lung disease (ILD). It seeks to determine the feasibility and effectiveness of this therapy when used alongside pulmonary rehabilitation. The research will involve adults with ILD and chronic cough lasting more than eight weeks, who will be recruited from outpatient programs and may participate through virtual interactions. The study will assess improvements in health-related quality of life and cough-related symptoms compared to pulmonary rehabilitation alone.

Why it matters

Potential benefit: If successful, this therapy could significantly improve the quality of life for patients suffering from chronic cough due to ILD.

How similar studies have gone: Previous studies have shown promise for non-pharmacological interventions in managing chronic cough, but this specific approach in ILD is novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Individuals will be included if having confirmed diagnosis of any ILD by a physician (as per Canadian Thoracic Society's guideline for evaluating patients with fibrotic interstitial lung disease) and a chronic cough lasting more than 8 weeks in duration

Exclusion Criteria:

* self-reports of moderate or large sputum production
* effective or suspected exacerbation of the respiratory condition in the past month
* upper respiratory tract infection in the past month
* use of angiotensin-converting enzyme inhibitor medication
* changes in the prescribed medication in the previous month
* evidence of traction bronchiectasis in the HRCT
* evidence of other medical conditions that prevent performance of an exercise training program
* unable to read or speak in English / unable to provide informed consent.

Where it's running

  • St. Joseph's Healthcare Hamilton
    Hamilton, Ontario, Canada
    Recruiting
  • West Park Healthcare Centre
    Toronto, Ontario, Canada
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.