Non-drug therapy for controlling cough in patients with lung disease
Official title: A Non-pharmacological Cough Control Therapy as an Adjuvant of Pulmonary Rehabilitation in People With Interstitial Lung Diseases and Chronic Cough - A Feasibility Study
Run by West Park Healthcare Centre · NCT04767074 · Data updated 2026-11-12
This study is testing a new non-drug therapy to help adults with interstitial lung disease and a long-lasting cough feel better when combined with pulmonary rehabilitation.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 85 Years |
| Sex | All |
| Enrollment | 24 (estimated) |
| Sponsor | West Park Healthcare Centre Academic / other |
| Locations | 2 sites (Hamilton, Ontario and 1 other locations) |
| Status | Recruiting |
| Started | September 1, 2020 |
| Main results expected | December 2025 |
| Study ends | December 2025 |
| Registry record updated | April 3, 2025 |
| Trial ID | NCT04767074 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults diagnosed with any form of interstitial lung disease and experiencing a chronic cough for over eight weeks.
✕Probably not a fit
Patients with significant sputum production, recent respiratory exacerbations, or other conditions that hinder exercise training may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates a non-pharmacological cough control therapy aimed at treating chronic cough in patients with interstitial lung disease (ILD). It seeks to determine the feasibility and effectiveness of this therapy when used alongside pulmonary rehabilitation. The research will involve adults with ILD and chronic cough lasting more than eight weeks, who will be recruited from outpatient programs and may participate through virtual interactions. The study will assess improvements in health-related quality of life and cough-related symptoms compared to pulmonary rehabilitation alone.
Why it matters
Potential benefit: If successful, this therapy could significantly improve the quality of life for patients suffering from chronic cough due to ILD.
How similar studies have gone: Previous studies have shown promise for non-pharmacological interventions in managing chronic cough, but this specific approach in ILD is novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Individuals will be included if having confirmed diagnosis of any ILD by a physician (as per Canadian Thoracic Society's guideline for evaluating patients with fibrotic interstitial lung disease) and a chronic cough lasting more than 8 weeks in duration Exclusion Criteria: * self-reports of moderate or large sputum production * effective or suspected exacerbation of the respiratory condition in the past month * upper respiratory tract infection in the past month * use of angiotensin-converting enzyme inhibitor medication * changes in the prescribed medication in the previous month * evidence of traction bronchiectasis in the HRCT * evidence of other medical conditions that prevent performance of an exercise training program * unable to read or speak in English / unable to provide informed consent.
Where it's running
-
St. Joseph's Healthcare Hamilton
Hamilton, Ontario, Canada Recruiting -
West Park Healthcare Centre
Toronto, Ontario, Canada Recruiting
Study contacts
- Study coordinator: Ana Oliveira, PhD
- Email: ana.oliveira@westpark.org
- Phone: 6477651525
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Remifentanil With or Without Lidocaine for Extubation After Thyroid Surgery
This study tests whether adding intravenous lidocaine to remifentanil during awakening reduces coughing after thyroidectomy extubation in adults.
-
Photon-counting CT vs standard HRCT to help diagnose IPF and other ILDs
This study tests whether photon-counting CT can improve identifying IPF and other ILDs compared with standard HRCT for patients discussed in multidisciplinary teams.
-
AccuPulmo CT Portal for Detecting Pulmonary Fibrosis on Chest CT
This study tests how well the AccuPulmo CT Portal can identify pulmonary fibrosis on existing chest CT scans from adults at Taichung Veterans General Hospital.
-
Oliceridine vs Sufentanil for cough during anesthesia induction
This trial tests whether oliceridine is better than sufentanil at reducing cough during anesthesia induction in adults undergoing elective surgery.
-
Advanced imaging to see how immunosuppression affects lung fibrosis activity
This trial will test whether immunosuppression changes PET and MRI measurements of active collagen deposition and tissue injury in people with non‑IPF interstitial lung disease who are starting treatment.
-
68Ga-NI-FAPI-04 PET/CT imaging to detect fibroblast activation in cancer, fibrotic, and heart diseases
This test will see if an injected PET tracer called 68Ga-NI-FAPI-04 can better show fibroblast activation in people with tumors, pulmonary fibrosis, certain autoimmune vascular diseases, hypertrophic cardiomyopathy, or other cardiovascular conditions.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.