Understanding how microbes and our bodies shape HIV-related COPD in LMICs
Official title: Harnessing multi-omics to identify host-microbiome interactions driving HIV-associated chronic obstructive pulmonary disease in low and middle income countries.
Funded at Duke University · NIH-11404969 · Data updated 2026-11-12
This project looks at how interactions between the human body and microbes may influence COPD in people living with HIV in low- and middle-income countries.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | September 25, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $530,717 |
| NIH project number | 5DP1HL174240-03 |
| Project ID | NIH-11404969 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults in high HIV prevalence settings (e.g., sub-Saharan Africa) with COPD or at risk for COPD, particularly those with HIV co-infection.
✕Less likely to help
Individuals without HIV or COPD or those not participating in biomarker or microbiome analyses may not directly benefit.
What this research studies
Researchers at Duke University will study how HIV and chronic lung disease interact with the body’s immune responses and the lung/microbial communities in populations in sub-Saharan Africa. The work will use multi-omics approaches to map inflammatory pathways and microbiome changes that relate to lung function in people with HIV. By comparing patients with HIV and COPD to those without HIV, the study aims to identify factors that could become new targets for therapy or prevention. The findings could inform better care for HIV-positive individuals suffering from COPD, both in LMICs and in high-income countries.
Why it matters
Potential benefit: A deeper understanding of HIV-related COPD could lead to more effective treatments and prevention strategies for patients.
How similar studies have gone: Previous work links inflammation and microbiome changes to COPD, but this project seeks to integrate host and microbial data in HIV-associated COPD, representing a novel, integrative approach.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Patel, Sweta Mahesh — Duke University
- Study coordinator: Patel, Sweta Mahesh
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.