How inflammation and blood clots affect heart and lung diseases
Official title: Inflammation and thrombosis fuel cardiovascular and pulmonary disease: Focus on the interplay of neutrophil inflammasomes with NETs
Funded at Boston Children's Hospital · NIH-11049092 · Data updated 2026-11-12
This study is looking at how certain immune responses, especially in older adults, can lead to heart and lung problems by causing inflammation and blood clots, and the researchers hope to find new ways to help treat these issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | March 15, 2023 |
| Project end | February 28, 2030 |
| Funding year | 2025 |
| Award (this year) | $1,115,101 |
| NIH project number | 5R35HL166556-03 |
| Project ID | NIH-11049092 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include older adults experiencing cardiovascular or pulmonary issues, particularly those with conditions like heart failure or chronic inflammation.
✕Less likely to help
Patients with acute, non-inflammatory conditions or those not affected by cardiovascular or pulmonary diseases may not benefit from this research.
What this research studies
This research investigates the relationship between inflammation, blood clots, and diseases affecting the heart and lungs, particularly focusing on neutrophil extracellular traps (NETs) and inflammasomes. The researchers aim to understand how these immune responses contribute to conditions like heart failure and pulmonary issues, especially in older adults. By studying the mechanisms of NET formation and their role in promoting inflammation and thrombosis, the team hopes to identify potential therapeutic targets to mitigate these effects. The approach includes both laboratory studies and animal models to explore the impact of inhibiting specific pathways involved in these processes.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce the risk of heart and lung diseases associated with inflammation and thrombosis.
How similar studies have gone: Previous research has shown promising results in understanding the role of inflammation and thrombosis in cardiovascular diseases, indicating that this approach has potential for significant advancements.
Where this research is happening
-
Boston Children's Hospital
Boston, United States Active
Researchers
- Principal investigator: Wagner, Denisa D — Boston Children's Hospital
- Study coordinator: Wagner, Denisa D
Related research
Other NIH-funded projects on the same topics.
-
Immune cell 'nets' and inflammation in heart and lung scarring
This project looks at how neutrophil 'nets' and inflammation help form blood clots and cause scarring in the heart and lungs.
-
Role of blood flow mechanics and transfusion in sepsis-related tiny-cl vessel clots
A patient-focused look at how red blood cell flow and transfusions might influence tiny blood vessel clots and organ problems in sepsis.
-
Ethics-aware Multimodal AI for COPD prevention, diagnosis, and treatment
A broad AI model uses diverse health data to help predict and manage COPD in people, with an emphasis on ethics and fairness.
-
New regimens to treat MAC lung disease in people with lung problems or weak immune systems
A study from Johns Hopkins aims to test new drug combinations to treat MAC lung disease in people with damaged lungs or weakened immune systems.
-
Understanding how DVT forms and heals to prevent vein scarring
This NIH grant supports a physician-scientist to study why deep vein clots form and how vein walls get scarred, with the goal of improving long-term outcomes for patients who develop DVT.
-
Piezo1’s role in blood clotting across vessels
Researchers are exploring how a tiny sensor in blood vessels called Piezo1 influences clot formation, with the aim of reducing clotting risks without causing dangerous bleeding.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.