How inflammation and blood clots affect heart and lung diseases
Inflammation and thrombosis fuel cardiovascular and pulmonary disease: Focus on the interplay of neutrophil inflammasomes with NETs
This study is looking at how certain immune responses, especially in older adults, can lead to heart and lung problems by causing inflammation and blood clots, and the researchers hope to find new ways to help treat these issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11049092 on NIH RePORTER |
What this research studies
This research investigates the relationship between inflammation, blood clots, and diseases affecting the heart and lungs, particularly focusing on neutrophil extracellular traps (NETs) and inflammasomes. The researchers aim to understand how these immune responses contribute to conditions like heart failure and pulmonary issues, especially in older adults. By studying the mechanisms of NET formation and their role in promoting inflammation and thrombosis, the team hopes to identify potential therapeutic targets to mitigate these effects. The approach includes both laboratory studies and animal models to explore the impact of inhibiting specific pathways involved in these processes.
Who could benefit from this research
Good fit: Ideal candidates for this research include older adults experiencing cardiovascular or pulmonary issues, particularly those with conditions like heart failure or chronic inflammation.
Not a fit: Patients with acute, non-inflammatory conditions or those not affected by cardiovascular or pulmonary diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce the risk of heart and lung diseases associated with inflammation and thrombosis.
How similar studies have performed: Previous research has shown promising results in understanding the role of inflammation and thrombosis in cardiovascular diseases, indicating that this approach has potential for significant advancements.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Wagner, Denisa D — Boston Children's Hospital
- Study coordinator: Wagner, Denisa D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.